Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Improving water utilization from a catchment perspective [PDF]
Water management / Water scarcity / Water use efficiency / Catchment areas / Calibrations / Hydrology / Models / River basins / Participatory management / Water balance / Case studies / Asia / Africa / South Africa ...
Batchelor, C. +3 more
core
Evaluation of the Water Footprint of Beef Cattle Production in Nebraska [PDF]
, 2020 Data were compiled on feed usage to model the amount of water needed to produce beef in typical Nebraska production systems. Production systems where cows were wintered on corn residue utilized 18% less water than systems utilizing native range as a ...
Erickson, Galen E. +5 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Groundwater research and management: integrating science into management decisions. Proceedings of IWMI-ITP-NIH International Workshop on "Creating Synergy Between Groundwater Research and Management in South and Southeast Asia," Roorkee, India, 8-9 February 2005 [PDF]
Groundwater management / Governance / Groundwater development / Artificial recharge / Water quality / Aquifers / Groundwater irrigation / Water balance / Simulation models / Watershed management / Water harvesting / Decision making / South East Asia ...
Sharma, Bharat R. +2 more
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Two-dimensional Moist Stratified Turbulence and the Emergence of Vertically Sheared Horizontal Flows
, 2011 Moist stratified turbulence is studied in a two-dimensional Boussinesq system influenced by condensation and evaporation. The problem is set in a periodic domain and employs simple evaporation and condensation schemes, wherein both the processes push ...
Majda, Andrew J. +2 more
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Modelling of water balance and nitrogen cycle in vegetative filter strips [PDF]
, 2006 The retention of nutrients by 10-m-wide grass buffers and buffers under natural vegetation has been studied over 10 years in Jokioinen in southwestern Finland. The results have been compared with those from 70-m-long plots without buffers. Grass was sown
Granlund, Kirsti +5 more
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The Cassie-Wenzel transition of fluids on nanostructured substrates: Macroscopic force balance versus microscopic density-functional theory [PDF]
, 2016 Classical density functional theory is applied to investigate the validity of a phenomenological force-balance description of the stability of the Cassie state of liquids on substrates with nanoscale corrugation.
Butt, Hans-Jürgen +5 more
core +2 more sources
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source