Results 81 to 90 of about 1,624,308 (352)

secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila [PDF]

, 2019
Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products.
Dent, J., Drapeau, P., Feingold, D., Knogler, L., Nilson, L., O'Donnell, M., Starc, T.   +6 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Ferromanganese nodules and micro-hardgrounds associated with the Cadiz Contourite Channel (NE Atlantic): Palaeoenvironmental records of fluid venting and bottom currents [PDF]

, 2012
Ferromanganese nodule fields and hardgrounds have recently been discovered in the Cadiz Contourite Channel in the Gulf of Cadiz (850–1000 m). This channel is part of a large contourite depositional system generated by the Mediterranean Outflow Water ...
Abouchami, Al-Aasm, Albarède, Ambar, Ambar, Baraza, Baturin, Beal, Berner, Berner, Berner, Birgel, Blinova, Boetius, Bogdanov, Borowski, Brass, Bryden, Cabeçadas, Cacho, Cangemi, Chen, Chen, Chester, Claude, Claypool, Coleman, Dicus, Díaz-del-Río, Ercilla, Faugères, Faugères, Faugères, Fernández-Puga, Fietzke, Fietzke, Fomina, Fortin, Francisco Javier González, Frankel, García, Gardner, Gardner, Giresse, Glasby, González, González, González, González, González, Grootes, Grootes, Hamoumi, Han, Hartmann, Hein, Hein, Hein, Hein, Hein, Hensen, Hernández-Molina, Hernández-Molina, Hernández-Molina, Hinrichs, Hlawatsch, Hodell, ISA, International Seabed Authority, Jesús Martínez-Frías, José Eugenio Ortiz, Kasten, Kennett, Kenyon, Kohn, Konshauser, Koschinsky, Koschinsky, Kozlova, León, León, León, León, León, Llave, Llave, Llave, Loubere, Lovley, Luis Somoza, Madelain, Magalhães, Maldonado, Mangini, Manheim, Martín-Puertas, Massé, Mazurenko, McArthur, McArthur, Medialdea, Medialdea, Meese, Merinero, Mulder, Munsell Color Co, Nealson, Nealson, Nelson, Nelson, Nelson, Niemann, O'Neill-Barringer, O'Nions, Ochoa, Palmer, Palmer, Paull, Pautot, Peckmann, Peckmann, Pinheiro, Piper, Platt, Puteanus, Raúl Merinero, Rebesco, Reyss, Ricardo León, Robinson, Rogers, Rona, Rosario Lunar, Scholz, Sevastýanov, Sivkov, Somoza, Stadnitskaia, Stadnitskaia, Stein, Stow, Stow, Stumpf, Summerhayes, Taylor, Tebo, Tebo, Templer, Teresa Medialdea, Trinidad de Torres, Tucholke, Usui, Vegas, Veizer, Viana, Voelker, von Stackelberg, Walters, Webb, Zahn, Zheng   +159 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Expression and localization of Aquaporin 1a in the sea-bass (Dicentrarchus labrax) during ontogeny

Frontiers in Physiology, 2011
The successful establishment of a species in a given habitat depends on the ability of each of its developing stages to adapt to the environment. In order to understand this process we have studied the adaptation of a euryhaline fish, the sea-bass ...
Ivone eGiffard-Mena, Viviane eBoulo, Charline eAbed, Gordon eCramb, Guy eCharmantier   +4 more
doaj   +1 more source

Optimal Transmit Covariance for Ergodic MIMO Channels [PDF]

, 2005
In this paper we consider the computation of channel capacity for ergodic multiple-input multiple-output channels with additive white Gaussian noise. Two scenarios are considered.
Grant, Alex J, Hanlen, Leif W
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Synergistic relationships among water resources, ecological environment, and social economy in the Lower Yellow River

Applied Water Science
The Lower Yellow River (LYR) is short of water resources. The imbalance and incoordination of water resources (WR), ecological environment (EE) and social economy (SE) have become the key constraints of regional sustainable development.
Yuhang Bian, Bo Qu, Enhui Jiang, Ying Liu, Lingang Hao, Hailong Wei   +5 more
doaj   +1 more source

Aquaporin Water Channels

Bioscience Reports, 2004
Thank you very much. I am humbled, I am delighted; I am honored. This is every scientist's dream: to give the Nobel Lecture in Stockholm. But I would not be honest if I did not tell you that I am having a little anxiety being on this platform. I have lectured a number of times in Sweden, and I thought I would share with you some events preceding a ...
openaire   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source