Results 61 to 70 of about 1,621,904 (302)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effect of Wettability and Adhesion Property of Solid Margins on Water Drainage

Biomimetics, 2023
Liquid flows at the solid surface and drains at the margin under gravity are ubiquitous in our daily lives. Previous research mainly focuses on the effect of substantial margin’s wettability on liquid pinning and has proved that hydrophobicity inhibits ...
Can Gao, Lei Jiang, Zhichao Dong
doaj   +1 more source

Seasonal behaviour of tidal damping and residual water level slope in the Yangtze River estuary: identifying the critical position and river discharge for maximum tidal damping [PDF]

, 2019
As a tide propagates into the estuary, river discharge affects tidal damping, primarily via a friction term, attenuating tidal motion by increasing the quadratic velocity in the numerator, while reducing the effective friction by increasing the water ...
Cai, Huayang, Garel, Erwan, Guo, Leicheng, Liu, Feng, Savenije, Hubert H. G., Yang, Qingshu, Zhang, Min, Zhang, Xianyi   +7 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

A study on the differences of turbulent flow properties along the open channel with submerged rigid vegetation

Shui kexue jinzhan
Submerged rigid vegetation causes uneven vertical distribution and streamwise differences of hydraulic parameters such as time-averaged flow velocity, turbulence intensity, and Reynolds stress by altering the flow structure. ADV is adopted to measure the
Yuejun CHEN, Lianjun ZHAO, Yao WANG, Zichun ZHU, Guangming TAN, Mingyang WANG   +5 more
doaj   +1 more source

Aquaporins in Cancer Biology

Frontiers in Oncology, 2022
Aquaporins (AQPs) are a family of transmembrane water channel proteins, which were initially characterized as a novel protein family that plays a vital role in transcellular and transepithelial water movement.
Chul So Moon, Chul So Moon, David Moon, David Moon, Sung Koo Kang, Sung Koo Kang   +5 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Scalable synthesis of ionic liquids: comparison of performances of microstructured and stirred batch reactors [PDF]

, 2012
A range of alkylpyridinium bromide ionic liquids have been synthesized in a stirred reactor at multigram scale and characterized by physical methods (viscosity, conductivity, melting point, electrochemical window, and water content).
Chaumat, Hélène, Guillen, Frédéric, Iken, Hicham, Mazières, Marie-Rose, Plaquevent, Jean-Christophe, Tzedakis, Théodore   +5 more
core   +3 more sources

Aquaporins: The renal water channels

Indian Journal of Nephrology, 2008
Water is the most abundant molecule in any cell. Specialized membrane channel, proteins called aquaporins, facilitate water transport across cell membranes. At least seven aquaporins (AQP): 1, 2, 3, 4, 6, 7, and 11 are expressed in the kidneys. Aquaporins play a role in both the short-term and long-term regulation of water balance as well as in the ...
Agarwal, S. K., Gupta, A.
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source