Results 41 to 50 of about 1,621,904 (302)
Structure and Function of Water Channels [PDF]
Current Opinion in Structural Biology, 2002 All aquaporins are efficient water transporters, while sustaining strict selectivity, even against protons, thereby maintaining the proton gradient across the cell membrane. Recently solved structures of these membrane channels have helped us to understand this remarkable property.
Fujiyoshi, Y. +6 more
openaire +4 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Journal of Agricultural Engineering, 2015 Although landslides are frequent natural phenomena in mountainous regions, the lack of data in emerging countries is a significant issue in the assessment of shallow landslide susceptibility.
Federico Preti, Tommaso Letterio
doaj +1 more source
Onion Root Water Transport Sensitive to Water Channel andK+ ChannelInhibitors [PDF]
Plant and Cell Physiology, 2001 Transroot osmotic water flux (Jos) and radial hydraulic conductivity (Lpr) in onion roots were greatly increased by three means; infiltration of roots by pressurization, repetition of osmosis and chilling at 5 degrees C. Jos was strongly reduced by the water channel inhibitor HgCl2 (91%) and the K+ channel inhibitor nonyltriethylammonium (C9, 75 ...
M, Tazawa, E, Sutou, M, Shibasaka
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Frontiers in Physiology, 2019 Besides lowering glucose, empagliflozin, a selective sodium-glucose cotransporter-2 (SGLT2) inhibitor, have been known to provide cardiovascular and renal protection due to effects on diuresis and natriuresis.
Sungjin Chung +7 more
doaj +1 more source
Energies, 2022 Designing an effective cooling system for high-power-density in-wheel motors of electric vehicles is required to avoid the irreversible demagnetization of the permanent magnet due to a rise in its temperature.
Jae Chang Bae +3 more
doaj +1 more source
, 1959 Water and supercritical carbon dioxide have different wetting angles to a glass surface, where water has a lower angle. In a microfluidic channel, the lower wetting angle draws the water to surround the supercritical carbon dioxide and the supercritical ...
Rogeman, Niklas
core +1 more source
Intermittent permeation of cylindrical nanopores by water
, 2002 Molecular Dynamics simulations of water molecules in nanometre sized cylindrical channels connecting two reservoirs show that the permeation of water is very sensitive to the channel radius and to electric polarization of the embedding material.
B. Smit +11 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source