Results 101 to 110 of about 2,321,749 (354)

Spatial Variations in the Surface Water Chemistry of Subtropical Peatlands (Central China) Linked to Anthropogenic Pressures [PDF]

, 2017
Yanmin Cao, Xu Chen, Zhao‐Jun Bu, Linghan Zeng   +3 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The comparison of water and matter flows in three small catchments in the Šumava Mountains

Soil and Water Research, 2009
The comparisons of water and matter flows have been evaluated in three small catchments with different land uses in the Šumava Mountains in the south-west of the Czech Republic since 1999. The catchment of the Mlýnský stream was artificially drained, the
Jan PROCHÁZKA, Jakub BROM, Libor PECHAR
doaj   +1 more source

Characterizing ground-water chemistry and hydraulic properties of fractured-rock aquifers using the multifunction Bedrock-Aquifer Transportable Testing Tool (BAT3) [PDF]

, 2001
Allen M. Shapiro
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The limnological character of bog pools in relation to meteorological and hydrological features [PDF]

Mires and Peat, 2012
As part of a major limnological characterisation of Rancho Hambre mire complex (Tierra del Fuego), five water bodies (bog pools) were sampled between October 2008 and April 2010 and their physico-chemical features studied in relation to meteorological ...
G. González Garraza, G. Mataloni, R. Iturraspe, R. Lombardo, S. Camargo, M.V. Quiroga   +5 more
doaj  

Molecular Dynamics Insights for Screening the Ability of Polymers to Remove Pesticides from Water

ChemistryOpen, 2019
The use of pesticides in agriculture is known to have environmental impacts, namely it leads to underground and spring water contamination. Thus, it turns out that nowadays general‐endeavor towards the sustainability of farmer production requires novel ...
F. G. A. Estrada, J. M. C. Marques, A. J. M. Valente   +2 more
doaj   +1 more source

Age and Land Use as Factors Differentiating Hydrochemistry and Plant Cover of Astatic Ponds in Post-Agricultural Landscape

Journal of Water and Land Development, 2014
Small, astatic ponds are important features of post-glacial landscape, which support heterogeneity and biodiversity of agricultural areas. In the presented research we explored differences in hydrochemistry and plant cover of 20 small ponds located in ...
Mętrak Monika, Pawlikowski Paweł, Suska-Malawska Małgorzata   +2 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source