Results 51 to 60 of about 452,167 (280)
Frontiers in Genetics, 2015 Most organisms anticipate daily environmental variations and orchestrate cellular functions thanks to a circadian clock which entrains robustly to the day/night cycle, despite fluctuations in light intensity due to weather or seasonal variations.
Quentin eThommen +5 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Circadian clock proteins in prokaryotes: hidden rhythms?
Frontiers in Cellular and Infection Microbiology, 2010 Circadian clock genes are vital features of eukaryotes that have evolved such that organisms can adapt to our planet’s rotation in order to anticipate the coming day or night as well as unfavorable seasons.
Maria eLoza-Correa +5 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Frontiers in Neuroscience, 2020 The sleep duration of adolescents has continued to decline over the past 20 years. Sleep insufficiency is one of the most important risk factors for obesity, but the mechanisms underlying the association are unclear. Therefore, the hypothalamic-regulated
Qi Sun +6 more
doaj +1 more source
Human-triggered earthquakes and their impacts on human security [PDF]
, 2010 A comprehensive understanding of earthquake risks in urbanized regions requires an accurate assessment of both urban vulnerabilities and earthquake hazards.
Christian Klose, Christian Klose
core +4 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Inhibition of casein kinase 1 δ/ε improves cognitive performance in adult C57BL/6J mice
Scientific Reports, 2021 Time-of-day effects have been noted in a wide variety of cognitive behavioral tests, and perturbation of the circadian system, either at the level of the master clock in the SCN or downstream, impairs hippocampus-dependent learning and memory.
Heather Mahoney +13 more
doaj +1 more source
Drought tolerance in Coffee: Identification of candidate genes and study of its natural variation : [Abstract W154] [PDF]
, 2010 Drought stress significantly affects coffee yield, productivity and quality. Thus, the goal of this study was to investigate the molecular mechanisms underlying the response to drought stress in coffee plants by different approaches.
Alves, Gabriel Sergio Costa +8 more
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