Results 61 to 70 of about 453,042 (281)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
WATER CLOCK SEDERHANA DENGAN PEMANFAATAN SISTEM TEKANAN
Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ, 2020 Pembuatan water clock (jam air) ini dilatarbelakangi oleh pentingnya penggunaan alat ukur waktu di setiap kegiatan. Water clock merupakan salah satu alat ukur waktu yang jarang dikembangkan dalam waktu sekarang ini karena proses pembuatan yang lumayan susah.
Fatiatun Fatiatun +3 more
openaire +2 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
PLoS Genetics, 2007 The mechanism of circadian oscillations in mammals is cell autonomous and is generated by a set of genes that form a transcriptional autoregulatory feedback loop. While these "clock genes" are well conserved among animals, their specific functions remain
Hee-Kyung Hong +7 more
doaj +1 more source
Scientific Realism without Rigid Designation in Kant's Analogies [PDF]
, 2016 In Kant, Science, and Human Nature, Robert Hanna argues against a version of scientific realism founded on the Kripke/Putnam theory of reference, and defends a Kant-inspired manifest realism in its place. I reject Kriple/Putnam for different reasons than
Landy, David
core
Rejuvenation by cell reprogramming: A new horizon in gerontology [PDF]
, 2018 The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation by cell reprogramming and the emerging view that aging is a reversible epigenetic process. Here,
Brown, Oscar Alfredo +5 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
The Unified Scale of Natural Waters
Georesursy, 2018 The article presents a continual scale of natural waters based on the characteristics of a vector, constructed on the superimposed cationic and anionic Gibbs triangles.
V.F. Nikolaev +5 more
doaj +1 more source
Parallel-in-Time Multi-Level Integration of the Shallow-Water Equations on the Rotating Sphere
, 2019 The modeling of atmospheric processes in the context of weather and climate simulations is an important and computationally expensive challenge. The temporal integration of the underlying PDEs requires a very large number of time steps, even when the ...
Hamon, Francois P. +2 more
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source