Results 41 to 50 of about 1,518,821 (245)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Morpho-physiological responses of Lycium ruthenicum Murr. propagated by tissue culture to drought stress

Mongolian Journal of Biological Sciences
To estimate the drought tolerance of Lycium ruthenicum Murr., which is propagated through tissue culture, we conducted a laboratory experiment to investigate the morphological and physiological responses of this species under various levels of drought ...
Tsogtbaatar Urjinlkham, Dalaikhuu Usukhjargal, Tovuu Altanzaya, Jambalsuren Bayarmaa, Shagjjav Oyungerel   +4 more
doaj   +1 more source

Research on Electromagnetic Sensitivity Properties of Sodium Chloride during Microwave Heating

High Temperature Materials and Processes, 2020
The multimode resonant cavity is the most common cavity. The material often shows on selective heating performance during the heating process due to the effect of microwave heating having a closely relationship with the electromagnetism parameters.
Chen Hua, Chen Junjiang, Wang Weijun, Lin Huan   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Physiological parameters formation of drought resistance in the process of adaptation of plants Ulmus pumila L. to adverse environmental factors in the conditions of the Astrakhan region

Siberian Journal of Life Sciences and Agriculture
Background.  The studies were carried out in the Astrakhan region, where dust storms are common and there is a deficit of precipitation. Only a few species of trees and shrubs can grow in this region, one of which is Ulmus pumila L.
Elena V. Kalmykova, Kristina A. Melnik, Anna I. Peredrienko   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Desenvolvimento e calibração de guias de onda para TDR Development and calibration of TDR wave guides

Revista Brasileira de Engenharia Agrícola e Ambiental, 2003
A medição da umidade do solo é crucial para a pesquisa e o manejo de irrigação. Entre os métodos mais recentes de determinação da umidade está o da reflectometria no domínio do tempo (TDR) que se baseia na correlação entre a capacidade dielétrica do solo
Camilo de L. T. de Andrade, Édio L. da Costa, Paulo E. P. de Albuquerque   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source