Results 161 to 170 of about 145,474 (264)

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Exploring the potential of foliar phytohormone application for mitigating water deficit in wheat cropping systems under arid soils. [PDF]

PLoS One
Abdelrhman AA, Fadl ME, Rebouh NY, Hefzy M, AbdElgalil MAS.   +4 more
europepmc   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Seed priming with two types of glassy microparticles in cowpea subjected to water deficit induced by polyethylene glycol 6000. [PDF]

BMC Plant Biol
Barroso VSF, Dias GF, de Alencar RS, Bonou SI, de Oliveira Viana PM, Cavalcante IE, da Silva Soares AC, da Costa Melo EM, Schneider R, de Luna Souto AG, de Mesquita EF, de Oliveira AMF, de Melo AS.   +12 more
europepmc   +1 more source

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

Advanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian, Yalan Wan, Chen Chen, Xiaoyu Zheng, Wenjing Du, Junhan Yang, Zhihao Quan, Biyu Yang, Jiaxi Yu, Jie Zheng, Zhaoxia Wang, Jianwen Deng, Qiang Guo   +12 more
wiley   +1 more source

The BoCML37-BoABA2 module positively regulates water-deficit tolerance in cabbage. [PDF]

Plant Physiol
Ji J, Liu Y, Wang C, Li Y, Zhang Y, Kuang L, Cao W, Lv H, Wang Y, Yang L, Zhuang M, Zhang Y.   +11 more
europepmc   +1 more source

Polydopamine Nanoparticle‐Mediated Precise Near‐Infrared Optical Stimulation for Cognitive Enhancement

Advanced Science, EarlyView.
Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou, Qiong Xue, Su‐Xuan Hou, Ke‐Yao Zhang, Wei‐Tong Pan, Ting‐Ting Zeng, Yu‐Ge Wang, Daqing Ma, Chenguang Zhao, Pan‐Miao Liu, Jian‐Jun Yang   +10 more
wiley   +1 more source

Do biomolecular condensates regulate the transcriptional and post-transcriptional responses of plant roots to water deficit? [PDF]

Quant Plant Biol
Masson C, Yu H, Bauget F, Gagliardi D, Boursiac Y.   +4 more
europepmc   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Foliar Application of Chitosan Nanoparticles Mitigates Early Physiological and Antioxidant Responses of <i>Solanum lycopersicum</i> L. Seedlings Under Mild-to-Moderate Water Deficit. [PDF]

Polymers (Basel)
Tighe-Neira R, Tortella-Fuentes G, Véjar-Cayuqueo V, Jorquera-Fontena E, González-Villagra J, Oliveira RJV, Sousa FLN, Araújo BGP, Rodríguez R, Inostroza-Blancheteau C.   +9 more
europepmc   +1 more source