Results 61 to 70 of about 248,175 (259)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Study the Dissociation Enthalpies for R134a Clathrate Hydrate in Binary and Ternary Systems

open access: yesAl-Khawarizmi Engineering Journal, 2018
In the present work the clathrate hydrate dissociation enthalpies of refrigerant R134a+ water system, and R134a + water + salt system were determined.
Riyadh S. AL Mukhtar   +2 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

To problem of hydrogen embrittlement of steel at droplet impingement erosion

open access: yesAdvanced Engineering Research, 2017
Introduction. The work is devoted to the problem of the hydrogen saturation of steel parts skin at their high-speed impacts with a water-drop flow. A hypothesis of the water molecules dissociation at high-speed drop impacts was suggested in a number of ...
Oleg V. Kudryakov   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim   +3 more
wiley   +1 more source

Enhanced Proton Spillover at Pt‐Cluster/NiO Interface Reduces the Acidic–Alkaline Hydrogen Evolution Activity Gap

open access: yesSmall Science
The sluggish hydrogen evolution reaction (HER) kinetics in alkaline media, primarily attributed to the additional water dissociation step, has led to a significant activity gap between acidic and alkaline conditions.
Ashwani Kumar   +3 more
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang   +10 more
wiley   +1 more source

Dynamic Characteristics of Offshore Natural Gas Hydrate Dissociation by Depressurization in Marine Sediments

open access: yesGeofluids, 2019
Dynamic characteristics of offshore natural gas hydrate (NGH) dissociation will provide the theoretical basis to analyze technical issues of oceanic hydrate exploitation.
Xinfu Liu, Chunhua Liu, Jianjun Wu
doaj   +1 more source

Controlling Chemical Reactions in Confined Environments: Water Dissociation in MOF-74

open access: yesApplied Sciences, 2018
The confined porous environment of metal organic frameworks (MOFs) is an attractive system for studying reaction mechanisms. Compared to flat oxide surfaces, MOFs have the key advantage that they exhibit a well-defined structure and present significantly
Erika M. A. Fuentes-Fernandez   +7 more
doaj   +1 more source

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