Results 71 to 80 of about 253,706 (260)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Enhanced Proton Spillover at Pt‐Cluster/NiO Interface Reduces the Acidic–Alkaline Hydrogen Evolution Activity Gap

Small Science
The sluggish hydrogen evolution reaction (HER) kinetics in alkaline media, primarily attributed to the additional water dissociation step, has led to a significant activity gap between acidic and alkaline conditions.
Ashwani Kumar, Jinsun Lee, Min Gyu Kim, Harun Tüysüz   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Dual active sites engineering of electrocatalysts for alkaline hydrogen evolution

Nano Research Energy
Hydrogen evolution reaction (HER) in alkaline medium plays an important role in producing green hydrogen but suffers from sluggish reaction kinetics owing to additional water dissociation step.
Wankun Gou, Hongming Sun, Fangyi Cheng
doaj   +1 more source

Study the Dissociation Enthalpies for R134a Clathrate Hydrate in Binary and Ternary Systems

Al-Khawarizmi Engineering Journal, 2018
In the present work the clathrate hydrate dissociation enthalpies of refrigerant R134a+ water system, and R134a + water + salt system were determined.
Riyadh S. AL Mukhtar, Shurooq T. AL Hemeri, Lina W. Mahmood   +2 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Phosphate Transport Through Homogeneous and Heterogeneous Anion-Exchange Membranes: A Chronopotentiometric Study for Electrodialytic Applications

Membranes
This study investigates the behavior of phosphate ion transport through two structurally distinct anion-exchange membranes—AMV (homogeneous) and HC-A (heterogeneous)—in an electrodialysis system under both static and stirred conditions at varying pH ...
Kayo Santana-Barros, Manuel César Martí-Calatayud, Svetlozar Velizarov, Valentín Pérez-Herranz   +3 more
doaj   +1 more source

To problem of hydrogen embrittlement of steel at droplet impingement erosion

Advanced Engineering Research, 2017
Introduction. The work is devoted to the problem of the hydrogen saturation of steel parts skin at their high-speed impacts with a water-drop flow. A hypothesis of the water molecules dissociation at high-speed drop impacts was suggested in a number of ...
Oleg V. Kudryakov, Valery N. Varavka, Vladimir A. Irkha, Irina V. Moiseeva   +3 more
doaj   +1 more source