Results 61 to 70 of about 1,670,487 (279)

Hydrological controls on river network connectivity [PDF]

, 2019
This study proposes a probabilistic approach for the quantitative assessment of reach- and network-scale hydrological connectivity as dictated by river flow space–time variability. Spatial dynamics of daily streamflows are estimated based on climatic and
Botter, Gianluca, Celegon, Elisa Alessi, Fanton, Pietro, Garbin, Silvia   +3 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Failures analysis of water distribution network during 2006-2008 in Ahvaz, Iran [PDF]

Journal of Advances in Environmental Health Research, 2013
Failures in the water distribution network are some most important factors in water losses, water shortage and dissatisfaction of users and secondary pollutions as well.
Mehdi Ahmadi, Mohammad-Javad Mohammadi, Kambiz Ahmadi-Angaly, Ali-Akbar Babaei   +3 more
doaj   +1 more source

Optimal Placement of Valves in a Water Distribution Network with CLP(FD)

, 2011
This paper presents a new application of logic programming to a real-life problem in hydraulic engineering. The work is developed as a collaboration of computer scientists and hydraulic engineers, and applies Constraint Logic Programming to solve a hard ...
Alvisi, Stefano, Cattafi, Massimiliano, Franchini, Marco, Gavanelli, Marco, Nonato, Maddalena   +4 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The first occurrence of the Ponto-Caspian invader, Hemimysis anomala G.O. sars, 1907 (Mysidacea) in the UK [PDF]

, 2007
An invasive Ponto-Caspian mysid, Hemimysis anomala G.O. Sars, 1907, was recorded in England for the first time in 2004. Usually a deep water species, in England H.
Harding, P, Stubbington, R, Terrell-Nield, CE   +2 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Evaluation of Municipal Water Distribution System Reliability Using Minimum Cut-set Method

Journal of King Saud University: Engineering Sciences, 2005
Reliability analysis of water distribution systems is a complex task, as it requires both definition and calculation of reliability measures. In this paper, a methodology for evaluating water distribution system reliability is developed and demonstrated ...
Muhammad A. Al-Zahrani, Juned Laiq Syed
doaj   +1 more source

Integrated Neural Based System for State Estimation and Confidence Limit Analysis in Water Networks [PDF]

, 1997
In this paper a simple recurrent neural network (NN) is used as a basis for constructing an integrated system capable of finding the state estimates with corresponding confidence limits for water distribution systems.
Bargiela, Andrzej, Gabrys, Bogdan
core