Results 71 to 80 of about 1,670,487 (279)

Modeling and optimization of production and distribution of drinking water at VMW [PDF]

, 2011
We develop and discuss an operational planning model aiming at minimizing production and distribution costs in large drinking water networks containing buffers with free inflow.
B. Ulanicki, J. Burgschweiger, J. Burgschweiger, P.D. Crawley, R.K. Ahuja, S. Pezeshk   +5 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

EVALUASI DEBIT DAN TEKANAN MELALUI SIMULASI KEBUTUHAN AIR PADA JARINGAN PIPA DISTRIBUSI AIR BERSIH KOTA KANDANGAN PROPINSI KALIMANTAN SELATAN

Teknologi dan Kejuruan, 2012
: Evaluation of Flow and Pressure Using Water Requirement  Simulation on Water  Distribution system in Kandangan, South Kalimantan. Certain locations in service region of clean water network pipe in Kandangan city South Kalimantan profince still ...
Rony Riduan, Achmad Rusdiansyah, Ery Suhartanto   +2 more
doaj   +1 more source

Robustness analysis of sensor placement for leak detection and location under uncertain operating conditions [PDF]

, 2016
Trabajo presentado a la 16th Water Distribution System Analysis Conference ( WDSA2014): Urban Water Hydroinformatics and Strategic Planning, celebrada en Bari (Italia) del 14 al 17 de julio.-- Under a Creative Commons license.Some pressure sensor ...
Blesa, Joaquim, Nejjari, Fatiha, Sarrate, Ramon   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Integrating the agent-based approach with hydraulic analysis of the water distribution network to a realistic micro-scale simulation of end-users in GAZ City, Iran

Journal of Hydrology: Regional Studies
Study region: GAZ City water distribution network in Isfahan province, Iran Study focus: In conventional water distribution network models, consumer water demand and water use behaviors are often oversimplified. These models are typically one-directional,
Zohre Fakhari, Azadeh Ahmadi
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Water distribution system modelling of GIS-remote sensing and EPANET for the integrated efficient design

Journal of Hydroinformatics
Urban settlement depends on water distribution networks for clean and safe drinking water. This research incorporates geographic information systems (GIS), remote sensing (RS), and hydraulic modelling software EPANET to analyse and construct water ...
Pranit Dongare, Kul Vaibhav Sharma, Vijendra Kumar, Aneesh Mathew   +3 more
doaj   +1 more source

Seismic Reliability Assessment of Water Distribution Networks

Procedia Engineering, 2014
AbstractA methodology for assessing the seismic risk in a WDN is presented here as obtained from the analysis of network mechanical reliability when pipe failures are due to earthquakes. The mechanical reliability analysis is performed considering WDN topological changes subsequent to multiple failure scenarios; while pipe failure probability law is ...
Laucelli D., Berardi L., Politano G., Giustolisi O.   +3 more
openaire   +1 more source