Results 41 to 50 of about 6,542 (216)

Fluorescence-informed water quality prediction in water distribution systems

Urban Lifeline
Conventional drinking water monitoring relies on laboratory-based chemical and microbiological analyses that are often time intensive. This study evaluates a rapid optical alternative by integrating excitation–emission matrix (EEM) fluorescence ...
Yi Xu, Mohamad Zeidan, Nicolas Peleato
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Water consumption time series forecasting in urban centers using deep neural networks

Applied Water Science
The time series analysis and prediction techniques are highly valued in many application fields, such as economy, medicine and biology, environmental sciences or meteorology, among others. In the last years, there is a growing interest in the sustainable
C. G. García-Soto, J. F. Torres, M. A. Zamora-Izquierdo, J. Palma, A. Troncoso   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Designing of water distribution system

Multidiszciplináris tudományok, 2021
Water distribution system (WDS) aims to distribute water from reservoirs or aqueducts to the end-users. This system is part of the water supply network that carries potable water from a central treatment plant or wells to water consumers in order to deliver water sufficiently to meet residential, commercial, industrial, and firefighting requirements ...
Amin, Osama Khasraw Mohammed, Akkad, Mohammad Zaher, Bányai, Tamás   +2 more
openaire   +3 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Operating Water Distribution Systems for Equitable Access to Clean Water

Engineering Proceedings
Water distribution systems (WDSs) are designed to deliver potable water across urban areas. Unpredicted changes in water demands and hydraulics can increase the residence time in pipes, leading to the growth of microbes and decreased water quality at ...
Brent Vizanko, Tomer Shmaya, Sriman Pankaj Boindala, Avi Ostfeld, Emily Berglund   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Water Distribution Network System

, 2023
The objective of this research is to ideal operation of water distribution networks can be posed as a scheduling problem where the objective is to meet the time-varying demand while meeting constraints on supply, pressure, etc. The first use of deep learning for the simulation, optimization, and operation control of water distribution networks is ...
Nilay Verma, Balram Shahu, Amit Verma, Rahul Yadav, Sohail Khan, Ravi Mishra   +5 more
openaire   +1 more source