Results 101 to 110 of about 2,388,439 (297)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Flume experimental study on evolution of a mouth bar under interaction of floods and waves
Water Science and Engineering, 2019 Based on the characteristics of hydrodynamics and sediment transport in the bar area in the Modaomen Estuary, a flume experiment was performed to study the evolution of the longitudinal profile of the mouth bar.
Li Yan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Development and Validation of a ReaxFF Reactive Force Field for Cu Cation/Water Interactions and Copper Metal/Metal Oxide/Metal Hydroxide Condensed Phases [PDF]
, 2010 To enable large-scale reactive dynamic simulations of copper oxide/water and copper ion/water interactions we have extended the ReaxFF reactive force field framework to Cu/O/H interactions.
Bryantsev, Vyacheslav S. +7 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The Role of Trees in Sand Dune Rehabilitation: Insights from Global Experiences
Applied SciencesThe present review summarizes the existing knowledge regarding the afforestation of sand dunes. Our main focus was on the role of trees in stabilizing and rehabilitating these complex ecosystems.
Lucian Dinca +5 more
doaj +1 more source
Quantum diffusion in liquid water from ring polymer molecular dynamics [PDF]
, 2005 We have used the ring polymer molecular-dynamics method to study the translational and orientational motions in an extended simple point charge model of liquid water under ambient conditions.
Manolopolous, David E. +1 more
core
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
The Journal for Transdisciplinary Research in Southern Africa, 2015 Strategies aimed at understanding contemporary South African water supply and sanitation problems require a broad view of factors such as migration, urbanisation and climate change.
Johann Tempelhoff
doaj +1 more source
, 2006 In a previous study, dissipative particle dynamics simulation was used to qualitatively clarify the phase diagram of the amphiphilic molecule hexaethylene glycol dodecyl ether (C12E6).
Español +12 more
core +2 more sources