Results 111 to 120 of about 2,388,439 (297)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Photodesorption of water ice: a molecular dynamics study

, 2008
Absorption of ultraviolet radiation by water ice coating interstellar grains can lead to dissociation and desorption of the ice molecules. These processes are thought to be important in the gas-grain chemistry in molecular clouds and protoplanetary disks,
Aikawa, Al-Halabi, Al-Halabi, Andersson, Andersson, Berendsen, Bergeld, Bergin, Bergin, Boonman, Caselli, Ceccarelli, Cuppen, d'Hendecourt, d'Hendecourt, Dalgarno, Dobbyn, Dominik, E. F. van Dishoeck, Ehrenfreund, Elles, Fraser, Garrod, Gerakines, Ghormley, Gibb, Hagen, Hartquist, Holtom, Jewitt, Jorgensen, Kimmel, Kimmel, Kobayashi, Léger, Mayer, Murakawa, Nishi, O'Neill, Palumbo, Pontoppidan, Pontoppidan, Pontoppidan, Prasad, S. Andersson, Shen, Smith, Snell, Snell, Spaans, Stäuber, Stäuber, van Dishoeck, van Harrevelt, van Harrevelt, Watanabe, Watanabe, Watanabe, Westley, Westley, Whittet, Willacy, Willner, Yabushita   +63 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Arctic–CHAMP: A program to study Arctic hydrology and its role in global change [PDF]

, 2002
The Arctic constitutes a unique and important environment that is central to the dynamics and evolution of the Earth system. The Arctic water cycle, which controls countless physical, chemical, and biotic processes, is also unique and important.
Bromwhich, David, Hamilton, Lawrence C., Hinzman, Larry, Morison, James, Peterson, Bruce, Romanovsky, Vladimir, Sturm, Matthew, Vorosmarty, Charles J., Webb, Robert   +8 more
core   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Results of trawl surveys in the Bering and Okhotsk Seas in autumn 2023

Известия ТИНРО
Results of trawl surveys in the Okhotsk Sea and western Bering Sea conducted aboard RV TINRO and RV Professor Kaganovsky in the autumn of 2023 are analyzed.
A. N. Starovoitov, S. S. Ponomarev
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Results of the trawl survey of nekton and macroplankton during preanadromous migrations of pacific salmon in the North-West Pacific in 2023

Известия ТИНРО
Results of the trawl survey in the Pacific waters at Kuril Islands within and outside EEZ of Russia conducted by RV TINRO in June-July 2023 are analyzed. Data on spatial distribution, abundance and biomass of fish, cephalopod and jellyfish species in the
A. N. Starovoytov
doaj   +1 more source