Results 101 to 110 of about 3,040,620 (306)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Discover Applied SciencesThe article presents forecast data on the impact of changing weather and climatic conditions on evaporation and water demand on the drained lands of Western Polissia of Ukraine in different periods of their development.
Anatoliy Rokochinskiy +6 more
doaj +1 more source
Engineering Problems in Water Fluoridation [PDF]
American Journal of Public Health and the Nations Health, 1952 BY and large, the solutions to the problems common to almost all fluoridation installations can be found in satisfactory answers to questions such as: How much fluoride should be added? Which fluoride compound should we use? How should we feed it? Where should it be applied? How should the operators be protected? How should we control it?
openaire +2 more sources
Application of NASA ERTS-1 satellite imagery in coastal studies [PDF]
There are no author-identified significant results in this report. Review of ERTS-1 imagery indicates that it contains information of great value in coastal engineering studies.
Berg, D. W. +2 more
core +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
FEBS Open Bio, EarlyView.Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source
iScienceSummary: The abnormal reproduction of algae in water worldwide is prominent in the context of human interference and global climate change. This study first thoroughly analyzed the effects of physical factors, such as light, temperature, hydrodynamics ...
Yuyao Wang +8 more
doaj +1 more source
Beach face dynamics as affected by ground water table elevations [PDF]
, 1992 This report presents the results of laboratory studies which were carried out in the Coastal and Oceanographical Engineering Laboratory to investigate the effects of ground water table elevations on the beach profile changes over the swash zone.
Dean, Robert G, Oh, Tae-Myoung
core