Results 51 to 60 of about 3,013,990 (285)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Varstvo okolja in univerzitetni študij tehnike ( = Environment protection and university technical curriculum) [PDF]
Geodetski Vestnik, 2015 This paper deals with a university degree in Environmental Engineering as a part of university studies in Engineering and shows engineering fields in which environmental engineering studies have been established as stand-alone studies globally ...
Matjaž Mikoš +2 more
doaj +1 more source
Water and erosion damage to coastal structures: South Carolina Coast, Hurricane Hugo, 1989 [PDF]
, 1990 Hurricane Hugo hit U.S. Mainland on September 21, 1989 just north of Charleston, South Carolina. It was billed as the most costly hurricane on record.
Wang, Hsiang
core
A way to measure the water quality of the LHAASO-WCDA with cosmic muon signals
, 2017 The Large High Altitude Air Shower Observatory (LHAASO) is to be built at Daocheng, Sichuan Province, China. As one of the major components of the LHAASO project, a Water Cherenkov Detector Array (WCDA), with an area of 78,000~$\rm m^{2}$, contains 350 ...
Bo Gao +10 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Men, Masculinities and Water Powers in Irrigation [PDF]
, 2008 The aim of this article is to provide an informed plea for more explicitly identifying, naming and unravelling the linkages between water control and gender in irrigation.
Zwarteveen, M.Z.
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Experimental Study on the Mechanical Properties of the Fiber Cement Mortar Containing Polyurethane
Advances in Materials Science and Engineering, 2021 Polymer is a kind of high molecular elastic material. The polymer cement mortar composite material formed by mixing it with cement mortar has the advantages of light weight, high strength, and good durability compared with traditional mortar materials ...
Xijun Zhang +4 more
doaj +1 more source