Results 71 to 80 of about 841,905 (263)

Stages of planning measures for engineering and environmental protection of water bodies – drainage water inlets from irrigated lands

Мелиорация и гидротехника
Purpose: to develop the main stages of planning the measures of engineering and environmental protection of water bodies – drainage water inlets from irrigated lands. Materials and methods.
Tatyana I. Drovovozova, Mikhail V. Vlasov, Natalia N. Krasovskaya   +2 more
doaj   +1 more source

Numerical Study for Negative Step Stilling Basin [PDF]

The Egyptian International Journal of Engineering Sciences and Technology
The hydraulic jump is considered one of the most effective methods in dissipating energy through the stilling basin downstream of the control structures.
Mohammad Nassar, Gamal Abdelaal, Hany Farahat, Abdelazim Tarbak, Ahmad Ismail, Eslam Eltohamy   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Co-engineering Participatory Water Management Processes: Theory and Insights from Australian and Bulgarian Interventions

Ecology and Society, 2010
Broad-scale, multi-governance level, participatory water management processes intended to aid collective decision making and learning are rarely initiated, designed, implemented, and managed by one person.
Katherine A. Daniell, Ian White, Nils Ferrand, Irina S. Ribarova, Peter Coad, Jean-Emmanuel Rougier, Matthew Hare, Natalie A. Jones, Albena Popova, Dominique Rollin, Pascal Perez, Stewart Burn   +11 more
doaj   +1 more source

Decision-Making Teaching Practice Based on the Maximum Entropy Method in a Water Engineering Economics Course. [PDF]

Entropy (Basel), 2023
Zhou R, Sun Y, Shao S, Zhang K, Zhang M.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Forecast assessment of water regime efficiency and changes in water consumption on drained lands of Western Polissia of Ukraine in a changing climate

Discover Applied Sciences
The article presents forecast data on the impact of changing weather and climatic conditions on evaporation and water demand on the drained lands of Western Polissia of Ukraine in different periods of their development.
Anatoliy Rokochinskiy, Pavlo Volk, Lyudmyla Kuzmych, Roman Koptyuk, Liubov Volk, Nataliia Prykhodko, Anna Kuzmych   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source