Results 111 to 120 of about 372,230 (299)
The power of pipes: Mapping urban water inequities through the material properties of networked water infrastructures - The case of Lilongwe, Malawi [PDF]
, 2018 Urban scholars have long proposed moving away from a conceptualisation of infrastructure as given and fixed material artefacts to replace it with one that makes it the very object of theorisation and explanation.
Maria Rusca +10 more
core
, 2018 When a sphere or a stream of water hits the surface of a pool of water and enters a crater or air cavity often forms. This topic has been studied, both formally and informally, for a long time. This dissertation investigates four areas of water impact that are still poorly understood using high-speed photography. First, it examines a stream of droplets
openaire +2 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Numerical Simulation of Water Entry with Improved SPH Method
, 2018 Water entry problems are very common in engineering and sciences. When objects move with relatively high speed, bubble cavities will be generated, and the behavior of moving objects will also be affected conversely.
M. B. Liu +3 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
A Prediction of Water-Entry Cavity Shape
, 1971 A method is described for predicting the shape of the cavity formed when a projectile enters the water vertically from air, as a function of time. The method, developed by Birkhoff and based on a hydraulic flow model, has been shown to be applicable for ...
H. I. Abelson
core +1 more source
水下无人系统学报The trans-medium vehicle is expected to quickly and stably break the free liquid surface. In addition, there are some problems in the trans-medium process, such as the damage to structures and instruments caused by the high impact load, cavity collapse ...
Zikun ZHEN, Zhihui ZOU, Yunhua JIANG
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source