Results 101 to 110 of about 6,679,972 (285)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
نشریه مهندسی دریا, 2018 The water entry problem of spherical projectile is simulated numerically and experimentally in this study. An explicit dynamic analysis method is employed to model the fluid-structure interaction using a Coupled Eulerian-Lagrangian (CEL) formulation that
Mohammad Hossein Taghizadeh Valdi +3 more
doaj
Investigation of the Impact Load Characteristics during Water Entry of Airdropped Underwater Gliders
Journal of Marine Science and EngineeringUnderwater gliders have emerged as effective tools for long-term ocean exploration. Employing aircraft for launching underwater gliders could significantly expand their application.
Xiangcheng Wu +3 more
doaj +1 more source
Water entry and related problems
, 2002 In this thesis we formalize, reconcile and generalize some existing mathematical models for deep- and shallow-water entry at small and zero deadrise angles for normal and oblique impact velocities. Our method throughout is to exploit the existence of one or more small parameters via the method of matched asymptotic expansions.
openaire +2 more sources
The Volume of Water Bills in the 1999 Virginia General Assembly
, 1999 The Virginia General Assembly held its 1999 session from January 13 to February 27. During the regular session, lawmakers considered 2,735 bills and resolutions, compared to 2945 measures considered in the longer 1998 session.
Virginia Water Resources Research Center
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Poster: Neighbors of water entry [PDF]
74th Annual Meeting of the APS Division of Fluid Dynamics - Gallery of Fluid Motion, 2021 Akihito Kiyama +3 more
openaire +1 more source
1998 General Assembly Legislation Related to Water
, 1998 The Virginia General Assembly held its regular session from January 14 to March 17, then reconvened April 22-23 to respond to the governor’s vetoes.
Manfre, Joseph +1 more
core
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source