Results 81 to 90 of about 372,230 (299)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The water entry of a sphere in a jet
Journal of Fluid Mechanics, 2019 The forces on an object impacting the water are extreme in the early moments of water entry and can cause structural damage to biological and man-made bodies alike. These early-time forces arise largely from added mass, peaking when the submergence is much less than one body length.
Nathan B. Speirs +6 more
openaire +3 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Free entry in infrastructure [PDF]
With a policy of free entry, individuals, firms, or community groups who wish to supply power, water, and sanitation services can do so with minimal legal restrictions. Free entry is the opposite of"exclusivity"or"legal monopoly".
Burdon, Rebecca, Ehrhardt, David
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Underwater Acoustics and Cavitating Flow of Water Entry
, 2004 The fluid mechanics of water entry is studied through investigating the underwater acoustics and the supercavitation. Underwater acoustic signals in water entry are extensively measured at about 30 different positions by using a PVDF needle hydrophone ...
Kume M +2 more
core
نشریه مهندسی دریا, 2018 The water entry problem of spherical projectile is simulated numerically and experimentally in this study. An explicit dynamic analysis method is employed to model the fluid-structure interaction using a Coupled Eulerian-Lagrangian (CEL) formulation that
Mohammad Hossein Taghizadeh Valdi +3 more
doaj
Study on Water Entry of a 3D Torpedo Based on the Improved Smoothed Particle Hydrodynamics Method
Applied SciencesThe water entry of a torpedo is a complex nonlinear problem, involving transient impact, free surface deformation, droplet splashing, and fluid–structure coupling, which poses severe challenges to traditional mesh methods.
Xiaowei Cai +5 more
doaj +1 more source
On Air-Cavity Formation during Water Entry of Flexible Wedges
Journal of Marine Science and Engineering, 2018 Elastic bodies entering water might experience fluid⁻structure interaction phenomena introduced by the mutual interaction between structural deformation and fluid motion. Cavity formation, often misleadingly named cavitation, is one of these.
Riccardo Panciroli +2 more
doaj +1 more source