Results 51 to 60 of about 372,230 (299)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Comparison of High-Speed Water Entry Movement Process of Axisymmetric Bodies with Different Head Shapes

open access: yes水下无人系统学报
High-speed water entry of the trans-medium axisymmetric body is an instantaneous flow process, involving the complex multiphase flow of the axisymmetric body with the gas and liquid phases.
Yu WANG   +5 more
doaj   +1 more source

Experimental Study and Numerical Simulation of the Water Entry of a Ship-Like Symmetry Section with an Obvious Bulbous Bow

open access: yesPolish Maritime Research, 2021
A bulbous bow is a typical ship structure. Due to the influence of the bulbous bow, complex flow separation and gas capture phenomena may appear during the water entry of ship-like sections.
Wang Qiang   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Water Entry Dynamics of Avian Inspired Divers

open access: yes, 2023
The mechanics of water entry has been investigated extensively for rigid and deformable media, for a wide range of engineering applications. Limited attention has been paid to understanding the water entry process of structural systems with both rigid ...
Truscott, Tadd   +4 more
core   +1 more source

The Dynamic Characteristics of the Water Entry of a Lifeboat

open access: yesJournal of Marine Science and Engineering
The International Convention for the Safety of Life at Sea (SOLAS) stipulates that all ships must be equipped with lifesaving devices. The freefall lifeboat has the advantages of simple operation, fast release speed, and good safety performance, so it is
Wenxin Yi   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

The hydrodynamics of ship sections entering and exiting a fluid [PDF]

open access: yes, 1998
This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel University.We study the hydrodynamics of wedge,knuckle and box cross-sectional profiles undergoing transient extreme motions, in particular forced entry and exit ...
Barringer, Ian Edward, Barringer, I.E.
core  

Water entry of spinning spheres [PDF]

open access: yesJournal of Fluid Mechanics, 2009
The complex hydrodynamics of water entry by a spinning sphere are investigated experimentally for low Froude numbers. Standard billiard balls are shot down at the free surface with controlled spin around one horizontal axis. High-speed digital video sequences reveal unique hydrodynamic phenomena which vary with spin rate and impact velocity.
Truscott, Tadd T., Techet, Alexandra H.
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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