Results 181 to 190 of about 7,416,707 (356)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Modern analogs for ammonia flux from terrestrial hydrothermal features to the Archean atmosphere
Scientific ReportsThe isotopic composition of nitrogen in the rock record provides valuable evidence of reactive nitrogen sources and processing on early Earth, but the wide range of δ15N values (− 10.2 to + 50.4‰) leads to ambiguity in defining the early Precambrian ...
J. David Felix
doaj +1 more source
Effect of Initial Water Flux on the Performance of Anaerobic Membrane Bioreactor: Constant Flux Mode versus Varying Flux Mode. [PDF]
Membranes (Basel), 2021 Yi X, Zhang M, Song W, Wang X.
europepmc +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
, 1997 A finite element numerical model is developed for the modeling of coupled surface-water flow and ground-water flow. The mathematical treatment of subsurface flows follows the confined aquifer theory or the classical Dupuit approximation for unconfined ...
Maddock, Thomas, III +2 more
core
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Impact of Organic Composition in Feed Water on Boron Flux and Membrane Scaling Potential
, 2019 Impact of Organic Composition inFeed Water on Boron Flux and Membrane Scaling ...
Kim, Lanhee
core
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Scattering <i>versus</i> fluorescence self-quenching: more than a question of faith for the quantification of water flux in large unilamellar vesicles? [PDF]
Nanoscale Adv, 2021 Wachlmayr J +6 more
europepmc +1 more source