Results 111 to 120 of about 556,228 (310)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Navigating the Currents: Land Use Challenges Amidst Water and Food Security Debates and Social Media Misperceptions

Land
This research aims to understand the complexities of energy deployment requiring nexus governance solutions. Nexus governance involves coordinating decision-making across policy areas and sectors, seeking compromise among stakeholders with varying ...
Nadejda Komendantova, Hossein Hassani, Mohammad Reza Yeganegi, Ahmed Al Salaymeh, Louy Qoaider   +4 more
doaj   +1 more source

Introducing a flat ontology into landscape research: a case study of water governance experiments in South Africa. [PDF]

Landsc Ecol, 2021
Raffn J, Christensen AA, de Witt M, Lewis C, Büchner-Marais C.   +4 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Supporting Water Governance and Climate Change Adaptation Through Systemic Praxis [PDF]

, 2013
Understanding and working with multiple perspectives on issues of change is an essential part of managing “common pool” water resources. In uncertain and complex situations arising from changes in human settlements and climate, both lives and livelihoods
Blackmore, Chris, Collins, Kevin, Ison, Ray   +2 more
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Gendered Social Norms Change in Water Governance Structures Through Community Facilitation: Evaluation of the UPWARD Intervention in Tanzania. [PDF]

Front Sociol, 2021
Eaton J, Krishna A, Sudi C, George J, Magomba C, Eckman A, Houck F, Taukobong H.   +7 more
europepmc   +1 more source

Implementing integrated river basin management: lessons from the Red River Basin, Vietnam [PDF]

River basin management / Water resource management / Legal aspects / Water law / Water policy / Institutional reform / Organizational change / Institutions / Governance / Development projects / Participatory management / Vietnam / Red River Basin / Cau ...
Hoanh, Chu Thai, Molle, Francois
core  

The potential role of socio-hydrological models for participatory water governance in Burkina Faso [PDF]

, 2020
Halting and reversing water quality degradation is a major global concern. The variety of needs and priorities placed on water resources make the issue of water pollution multifaceted and complex.
Barendrecht, Marlies, Carr, Gemma, Debevec, Liza   +2 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source