Results 91 to 100 of about 556,228 (310)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Caring for Groundwater: How Care Can Expand and Transform Groundwater Governance

International Journal of the Commons
Efforts to measure and regulate groundwaters and irrigators are notoriously ineffective. The starting point of this article, therefore, is to question the continued faith in techno-managerial solutions to groundwater depletion.
Margreet Zwarteveen, Carolina Domínguez-Guzmán, Marcel Kuper, Amine Saidani, Jeltsje Kemerink-Seyoum, Frances Cleaver, Himanshu Kulkarni, Lisa Bossenbroek, Hind Ftouhi, Andres Verzijl, Uma Aslekar, Zakaria Kadiri, Tavengwa Chitata, Irene Leonardelli, Seema Kulkarni, Sneha Bhat   +15 more
doaj   +1 more source

A systematic review on the role of trust in the water governance literature. [PDF]

Water Res X, 2022
Voogd R, Rudberg PM, de Vries JR, Beunen R, Espiritu AA, Methner N, Larsen RK, Fedreheim GE, Goes S, Kruger E.   +9 more
europepmc   +1 more source

Multilevel governance patterns and the protection of groundwater and drinking water in Florida and the Netherlands [PDF]

, 2000
This paper develops a model of ‘governance’ as an aid for comparing such\ud governance structures and applies these to a particular policy arena: policies\ud on the protection of groundwater and on drinking water quality in the\ud Netherlands and Florida.
Bressers, J.T.A., Kuks, S.M.M.
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A multi-model ensemble approach for reservoir dissolved oxygen forecasting based on feature screening and machine learning

Ecological Indicators
Dissolved oxygen (DO) concentration in aquatic systems plays a vital role in water aquaculture. An innovative approach that combines feature selection and ensemble learning to predict DO in aquatic ecosystems was proposed.
Peng Zhang, Xinyang Liu, Huancheng Dai, Chengchun Shi, Rongrong Xie, Gangfu Song, Lei Tang   +6 more
doaj   +1 more source

The role and interplay of institutions in water governance in the Central Rift Valley of Ethiopia. [PDF]

F1000Res, 2023
Jibat E, Senbeta F, Zeleke T, Hagos F.
europepmc   +1 more source

Water Governance for Urban Resilience Analysis of Key Factors and the Role of Stakeholders in Metropolitan Area [PDF]

, 2017
Water governance is critical for water security and as enabling condition to achieve urban resilience. Water governance involves multi-actor, multi-sector and multi-level.
Mulyana, W. (Wahyu), Suganda, E. (Emirhadi)   +1 more
core   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Modeling water flow and volumetric water content in a degraded peat comparing unimodal with bimodal porosity and flux with pressure head boundary condition

Vadose Zone Journal
Degraded peatlands release large amounts of greenhouse gases. The development of effective mitigation and management measures requires an understanding of relevant site‐specific biogeochemical and hydraulic processes.
Mariel F. Davies, Ottfried Dietrich, Horst H. Gerke, Christoph Merz   +3 more
doaj   +1 more source