Results 81 to 90 of about 556,228 (310)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
IWMI Strategic plan 2009-2013: water for a food-secure world [PDF]
Strategy planning / Research institutes / Institutional development / Research priorities / Water resource management / Water ...
International Water Management Institute (IWMI).
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A river basin as a common-pool resource: a case study for the Jaguaribe basin in Brazil [PDF]
, 2007 Rainfall variability and the associated water stress are of major concern in semi-arid regions subject to conflicts between water users. To achieve sustainable and stable agricultural performance it is necessary to understand\ud the interaction between ...
Hoekstra, A.Y. +2 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Decolonising Canadian water governance: lessons from Indigenous case studies. [PDF]
UCL Open Environ, 2023 McKibbin C.
europepmc +1 more source
The governance of Singapore’s knowledge clusters: off shore marine business and waterhub [PDF]
, 2011 Based on two case studies of knowledge clusters (off shore marine/rig business and water hub) in Singapore, the paper illustrates the importance of good knowledge governance in creating robust and value-creating knowledge clusters.
Evers, Hans-Dieter, Menkhoff, Thomas
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Impact of Three Gorges Project Impoundment on Spatiotemporal Variation of Pollutant Flux in Mainstream Yangtze River [PDF]
长江科学院院报[Objective] To investigate the variation patterns of pollutant fluxes in the Yangtze River mainstream before and after the operation of the Three Gorges Project, this study analyzes the annual variations in water quality, runoff, and pollutant fluxes at ...
PENG Lian, ZHAO Min, QIAN Bao, ZHOU Bing-yi
doaj +1 more source
Engagement in water governance action situations in the Lake Champlain Basin. [PDF]
PLoS One, 2023 Bitterman P, Koliba C.
europepmc +1 more source
Water Figures Africa: news of IWMI’s work in Africa [PDF]
Water resource management, Water use, Governance, Food security, Irrigated farming ...
International Water Management Institute (IWMI).
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