Results 71 to 80 of about 37,245 (263)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Construction and application of a real-time irrigation decision system based on the multiple sources data assimilation and weather forecasts

Agricultural Water Management
Improving irrigation strategies is essential for increasing irrigation water productivity (IWP) while maintaining crop yield. We developed a real-time irrigation decision system that couples the soil-water-atmosphere-plant (SWAP) crop simulation model ...
Boyan Sun, Zheng Guo, Taiyu He, Yimin Ding, Lei Zhu, Yuanyuan Zha   +5 more
doaj   +1 more source

The role and interplay of institutions in water governance in the Central Rift Valley of Ethiopia. [PDF]

F1000Res, 2023
Jibat E, Senbeta F, Zeleke T, Hagos F.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Caring for Groundwater: How Care Can Expand and Transform Groundwater Governance

International Journal of the Commons
Efforts to measure and regulate groundwaters and irrigators are notoriously ineffective. The starting point of this article, therefore, is to question the continued faith in techno-managerial solutions to groundwater depletion.
Margreet Zwarteveen, Carolina Domínguez-Guzmán, Marcel Kuper, Amine Saidani, Jeltsje Kemerink-Seyoum, Frances Cleaver, Himanshu Kulkarni, Lisa Bossenbroek, Hind Ftouhi, Andres Verzijl, Uma Aslekar, Zakaria Kadiri, Tavengwa Chitata, Irene Leonardelli, Seema Kulkarni, Sneha Bhat   +15 more
doaj   +1 more source

Adaptive Water Management: On the Need for Using the Post-WWII Science in Water Governance. [PDF]

Water Resour Manag (Dordr), 2023
Hjorth P, Madani K.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Modeling water flow and volumetric water content in a degraded peat comparing unimodal with bimodal porosity and flux with pressure head boundary condition

Vadose Zone Journal
Degraded peatlands release large amounts of greenhouse gases. The development of effective mitigation and management measures requires an understanding of relevant site‐specific biogeochemical and hydraulic processes.
Mariel F. Davies, Ottfried Dietrich, Horst H. Gerke, Christoph Merz   +3 more
doaj   +1 more source

A multi-model ensemble approach for reservoir dissolved oxygen forecasting based on feature screening and machine learning

Ecological Indicators
Dissolved oxygen (DO) concentration in aquatic systems plays a vital role in water aquaculture. An innovative approach that combines feature selection and ensemble learning to predict DO in aquatic ecosystems was proposed.
Peng Zhang, Xinyang Liu, Huancheng Dai, Chengchun Shi, Rongrong Xie, Gangfu Song, Lei Tang   +6 more
doaj   +1 more source

Reflecting on twenty years of international agreements concerning water governance: insights and key learning. [PDF]

Int Environ Agreem, 2022
Mirumachi N, Hurlbert M.
europepmc   +1 more source