Results 121 to 130 of about 549,261 (292)

We must account for the results of water governance to deliver the SDGs and beyond

Environmental Research: Water
The crisis of water governance is one of results. This perspectives paper argues that we need to move beyond calling the global water crisis a crisis of governance.
Dustin Garrick, Gina Gilson, Rob Hope, Johannes Wagner, Graham Epstein, Elisha Ochieng Okoth, Fridah Silas   +6 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Aligning local governance with SDGs: a study of local government systems in Pakistan

Development Studies Research
This study examines the experiences of local government councilors between 2013–2020 in four provinces of Pakistan. The study addresses three key questions: Firstly, it investigates the differences and commonalities in the local government structures ...
Abdur Rehman Cheema, Iftikhar Ahmad, Abid Mehmood   +2 more
doaj   +1 more source

Agriculture in a Water-Scarce World [PDF]

With a relatively small population and 7% of the world's available freshwater resources, Canada is well placed for a world of water scarcity where the real value of water in its many uses becomes more and more apparent.
Deng, Hugh, Gilmour, Brad, Gurung, Rajendra Kumar, Jotanovic, Aleksandar, Polcyn, Tania   +4 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Attitudes of political-administrative decision makers towards the implementation of nature-based solutions in water management – a case study on a hypothetical constructed wetland in the Tárcoles River basin

Ecosystems and People
Nature-based solutions (NBS) are actions that help communities address social-ecological challenges such as flooding and polluted groundwater. Nevertheless, research shows that in practice, NBS confront several barriers in planning and implementation ...
Franka Pätzke, Christoph Schulze, Jochen Hack, Karina Castro-Arce, Veronica Alejandra Neumann, Barbara Schröter   +5 more
doaj   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Vernacular Knowledge and Water Management – Towards the Integration of Expert Science and Local Knowledge in Ontario, Canada

Water Alternatives, 2015
Complex environmental problems cannot be solved using expert science alone. Rather, these kinds of problems benefit from problem-solving processes that draw on 'vernacular' knowledge.
Hugh Simpson, Rob de Loë, Jean Andrey
doaj  

Citizen participation dilemmas in water governance: An empirical case of Kumasi, Ghana. [PDF]

World Dev Perspect, 2020
Odei Erdiaw-Kwasie M, Abunyewah M, Edusei J, Buernor Alimo E.   +3 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source