Results 61 to 70 of about 902,226 (264)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Groundwater quality assessment methods in the Hongyuan−Ruo’ergai Ecological Reserve

Shuiwen dizhi gongcheng dizhi
Groundwater is a critical component of water resources that supports ecosystem functioning and sustains human water demand. However, the pathways and mechanisms through which changes in groundwater quality affect ecosystems differ fundamentally from ...
Hao LIU, Qinqin HUANG, Yong LIU, Xin HUANG, Lindong HE, Yanming LIU   +5 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Vulnerability Liquefaction Mapping in Padang City Based on Cloud Computing Using Optical Satellite Imagery Data

JOIV: International Journal on Informatics Visualization
Liquefaction is a significant geological hazard in earthquake-prone locations like Padang City, Indonesia. The phenomenon happens when saturated soil loses strength owing to seismic shaking, resulting in substantial infrastructure damage.
Pakhrur Razi, Amalia Putri, Josaphat Tetuko Sri Sumantyo, - Akmam   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Changes in the Lake Area of Tonle Sap: Possible Linkage to Runoff Alterations in the Lancang River?

Remote Sensing, 2018
Tonle Sap Lake is the largest freshwater lake in Southeast Asia. Water development infrastructures are increasingly being constructed in the Lancang–Mekong River Basin, which is a major concern considering its potential impact on Tonle Sap Lake ...
Xuan Ji, Yungang Li, Xian Luo, Daming He
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Monitoring plateau lake area changes in Yunnan province, southwestern China using medium-resolution remote sensing imagery: applicability of water indices and environmental dependencies

Open Physics
Lake area dynamics are closely linked to climate change, and accurate shoreline extraction is critical for monitoring lake area changes, with significant implications for water resource management, ecological conservation, and regional sustainable ...
Fu Jingyi, Liu Yong
doaj   +1 more source

Evaluating the Sustainable Development Science Satellite 1 (SDGSAT-1) Multi-Spectral Data for River Water Mapping: A Comparative Study with Sentinel-2

Remote Sensing
SDGSAT-1, the first scientific satellite dedicated to advancing the United Nations 2030 Agenda for Sustainable Development, brings renewed vigor and opportunities to water resource monitoring and research. This study evaluates the effectiveness of SDGSAT-
Duomandi Jiang, Yunmei Li, Qihang Liu, Chang Huang   +3 more
doaj   +1 more source