Results 41 to 50 of about 6,484,050 (283)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Research on Integrated String for Gas Lift and Water Injection in HTHP and Sour Content Wells

Shiyou jixie, 2017
In order to realize full production of crude oil in some oil wells with high gas-oil ratio in Tazhong Oilfield in Tarim Basin, an integrated string for gas lift and water injection has been designed.
Chen Defei, Meng Xiangjuan, Bai Xiaofei, Peng Yonghong, Wang Peng, Ju Chengcai   +5 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Study on Jet Pump Water Injection System for Offshore Platform Based on Energy Conservation

Shiyou jixie, 2017
In order to reduce the energy consumption of water injection in offshore platform, the idea of using jet pump instead of wellhead gate valve has been put forward. Taking the 14 water injection wells on a Bohai platform as case study, the JP1, JP2 and JP3
Wang Xiaohe, Yan Tingjun, Xie Shuangxi, Yu Jifei   +3 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Experimental Study on Water Injection Removal of Ammonium Chloride Particles to Enhance Hydrotreatment Air Cooler Reliability

Fuels
Hydrotreatment is vital for producing high-quality liquid fuels in petroleum refining and its air coolers are critical components prone to severe corrosion under high-temperature and high-pressure conditions.
Xiaofei Liu, Xin Chen, Zhengwei Zhang, Huayu Wen, Dongbo Chen, Haoyu Yin, Haozhe Jin, Chao Wang, Lite Zhang   +8 more
doaj   +1 more source

Experimental Analysis of Water Pressure and Temperature Influence on Atomization and Evolution of a Port Water Injection Spray

Applied Sciences, 2021
Port water injection (PWI) is considered one of the most promising technologies to actively control the increased knock tendency of modern gasoline direct injection (GDI) engines, which are rapidly evolving with the adoption of high compression ratios ...
Lucio Postrioti, Gabriele Brizi, Gian Marco Finori   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Simulation study of water and gas injection process into the Azadegan reservoir for enhanced oil recovery

Engineering Reports
It is necessary to improve oil production from reservoirs. Various methods have been proposed to increase oil extraction from reservoir. Each method has specific challenges. In this research, the effect of water and gas injection in to Azadegan reservoir
Farshad Farahbod
doaj   +1 more source

Numerical Simulation of CO₂-EGR and Storage by Injecting Supercritical CO₂ and Water in Depleted Gas Reservoirs

Energies
The injection of CO2 into mature natural gas reservoirs is widely recognised for its potential to store carbon dioxide while simultaneously enhancing natural gas recovery. However, across all reservoir pressure and temperature ranges, CO2 and natural gas
Adeltus Novat Rweyemamu, Yuichi Sugai, Takehiro Esaki, Theodora Tambaria   +3 more
doaj   +1 more source