Results 61 to 70 of about 6,484,050 (283)
Water Injection for Cloud Cavitation Suppression: Analysis of the Effects of Injection Parameters
Journal of Marine Science and EngineeringThis study investigates cloud cavitation suppression around a model-scale NACA66 hydrofoil using active water injection and explores the effect of multiple injection parameters.
Wei Wang +4 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Water in the 2003 Virginia General Assembly
, 2003 The 2003 Virginia General Assembly convened on January 8 and adjourned on February 22, with a reconvened (“veto”) session on April 2. The legislature considered 3277 measures; 1585 passed and 1692 failed. The legislature also considered amendments to the
Virginia Water Resources Research Center
core
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Water in the 2007 Virginia General Assembly
, 2007 The 2007 Virginia General Assembly convened January 10, adjourned February 24, and held a reconvened (“veto”) session on April 4. During the session, the Assembly considered 3427 measures (3069 introduced in this session and 358 continued from the 2006 ...
Virginia Water Resources Research Center
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Water in the 2000 Virginia General Assembly
, 2000 The Virginia General Assembly held its 2000 session from January 12 to March 10. Lawmakers considered 3,172 bills and resolutions (compared to 2,735 measures considered in 1999).
Virginia Water Resources Research Center
core
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source