Results 31 to 40 of about 362,459 (244)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Frontiers in Aging Neuroscience, 2020 Aging results in decreased fluid intake following dehydration and other dipsogenic stimuli; similar reductions in sodium intake have also been observed with aging.
Denovan P. Begg +2 more
doaj +1 more source
Geriatrics, Gerontology and Aging, 2022 Objective: The goal of this study is to evaluate the benefits of an increase in water intake guided by a mathematical formula (per kg of body weight) on kidney function in older adults.
Mariana Rangel Ribeiro Falcetta +6 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
On air-entraining flow in pump's sump with a vertical suction pipe below critical submergence
Journal of Fluid Science and Technology, 2019 In pump’s sumps, the air entrainment sometimes occurs. Such flow accompanying the air entrainment becomes complicated owing to both of its unsteadiness with poor periodicity and its fully-three-dimensionality.
Katsuya HIRATA +4 more
doaj +1 more source
Performance of Holstein-Friesian calves drinking desalinated water in the preweaning period
Revista Colombiana de Ciencias Pecuarias, 2022 Background: High salinity of drinking water can adversely affect health and productive performance of calves during artificial rearing. Objective: To evaluate the effect of drinking water total dissolved salts (TDS) content on productive performance of ...
Joel Ventura-Ríos +6 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effects of Water Intake Layout along the Wharf Shoreline on Ships
Polish Maritime Research, 2019 The construction of a water intake along the wharf shoreline can realise the intensive and comprehensive utilisation of the shoreline. However, since the water intake will increase the lateral flow at the wharf and also the hydrodynamic forces on ships ...
Kong Xian-wei +4 more
doaj +1 more source
Occurrence Condition of Air Entrainment into a Vertical Wet-Pit Pump
Journal of Fluid Science and Technology, 2013 In the present study, we consider the air entrainment into a suction pipe which is vertically inserted down into a suction sump across a mean free-water surface.
Katsuya HIRATA +5 more
doaj +1 more source