Results 121 to 130 of about 6,679,528 (309)

Multicriteria Modelling of Irrigation Water Market at Basin Level [PDF]

open access: yes
This paper develops a multi-criteria methodology to simulate irrigation water markets at basin level. For this purpose it is assumed that irrigators try to optimise personal multi-attribute utility functions via their productive decision making process ...
José A. Gómez-Limón   +1 more
core  

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

RWU Kicks Off “State of the Ocean” Series with Lecturer, Book Examining Impact of Sea-Level Rise [PDF]

open access: yes, 2018
Sea-level rise is one of the most pressing issues of our time, bringing with it potentially devastating impacts on the environment and humanity. As a campus surrounded by water and in a state where most of the population lives near water, Roger Williams ...
Public Affairs, Roger Williams University
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Natural resources governance scales and social learning approaches in peri-urban areas: Contribution experience in Bolivia and Brazil [PDF]

open access: yes, 2008
Competition for water, often associated with a struggle for land, tends to be exacerbated in pen-urban areas because of the conflicting interests of the users, a dynamic land use pattern and specific hydrological functions provided to the city.
Ducrot, Raphaèle
core  

A Simple Flood Forecasting Scheme Using Wireless Sensor Networks

open access: yes, 2012
This paper presents a forecasting model designed using WSNs (Wireless Sensor Networks) to predict flood in rivers using simple and fast calculations to provide real-time results and save the lives of people who may be affected by the flood.
Maity, Shovan   +5 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

open access: yesMolecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Water Use in China’s Domestic, Industrial and Agricultural Sectors: An Empirical Analysis [PDF]

open access: yes
Demand management plays an increasingly important role in dealing with water scarcity in China. It is important to understand the level and pattern of water use in various sectors across the regions for any measures being put into effect. The aim of this
Richard S.J. Tol, Zhou Yuan
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

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