Results 121 to 130 of about 2,393,042 (266)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Group-specific effect of interannual water level fluctuation on consumers trophic niche area. [PDF]

Sci Rep
Veselý L, Ruokonen TJ, Ercoli F, Bláha M, Buřič M, Balzani P.   +5 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Community-based nearshore wave and water level monitoring in Nunavut, Arctic Canada 2021-2023. [PDF]

Sci Data
Didier D, Zouaghi F, Coulombe S, Noah T, Bertrand EM, Stolle J, Jourdain-Bonneau C, Baudry J, Binette S, Nicot P, Akana R, Noël B, Boisson A, Dubuc D, Berry B, Ferland G, Lafosse L, Omonigbehin O, Stancu C, Guay CA, Said HB, White P, Heras Duran A, Audlaluk Watsko L, Qaapik J, Walch DMR, Hallé D, Parrott C, Spence J, Hamilton AK, Quénet Y, Gagnon S, Bélanger S, Bouchard F, Kurylyk B, Chaillou G, Dumont D, Myers P, Eamer J, Normandeau A, Bhatia M.   +40 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Improving coastal water level estimation by merging nadir-only satellite altimetry data into a hydrodynamic model. [PDF]

Environ Monit Assess
Bhuiyan SA, De Lima AS, Miesse T, Henke M, Ferreira C, Maggioni V.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Development of Real-Time Water-Level Monitoring System for Agriculture. [PDF]

Sensors (Basel)
Borankulova G, Altybayev G, Tungatarova A, Yeraliyeva B, Dulatbayeva S, Murzakhmetov A, Bekbolatov S.   +6 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Penetration explosion damage and discharge of high arch dam with high reservoir water level. [PDF]

Sci Rep
Wu L, Wu A, Yu C, Huang R, Zhou J.
europepmc   +1 more source