Results 111 to 120 of about 6,679,528 (309)

Study on the Impact of Groundwater and Soil Parameters on Tunnel Deformation and Sensitivity Analysis

open access: yesApplied Sciences
Based on the Xiaolangdi North Bank Irrigation Area Project, this study combines numerical simulation and BP neural network methods to investigate the sensitivity of tunnel soil and its parameter inversion under continuous heavy rainfall.
Yongxin Li   +4 more
doaj   +1 more source

Some considerations on coastal processes relevant to sea level rise [PDF]

open access: yes, 1987
The effects of potential sea level rise on the shoreline and shore environment have been briefly examined by considering the interactions between sea level rise and relevant coastal processes.
Dally, William R.   +3 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Ghana Market Assessment: Market-Based Provision of Water at the Community Level [PDF]

open access: yes, 2013
This market assessment evaluates the potential for decentralized market-based approaches to sustainable safe water service, focusing on the poor in rural communities and small towns in Ghana that are not supplied or connected by municipal schemes to safe

core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Mitigating the water footprint of export cut flowers from the Lake Naivasha Basin, Kenya [PDF]

open access: yes, 2010
Kenya’s cut-flower industry has been praised as an economic success as it contributed an annual average of US$ 141 million foreign exchange (7% of Kenyan export value) over the period 1996-2005 and about US$ 352 million in 2005 alone.
Hoekstra, A.Y., Mekonnen, M.M.
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Water Level Indicator

open access: yes, 2020
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openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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