Results 91 to 100 of about 15,780,718 (239)

Sea level variability in South African estuaries

South African Journal of Science, 2013
Sea level variability in the coastal ocean affects water levels in adjacent estuaries over a wide range of periods and to varying distances landward. An assessment is given here of the responses of a number of South African estuaries, focusing on tidal ...
Eckart H. Schumann
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Report (Texas Water Development Board)

, 2004
A guide on the practices, techniques, programs, and technologies that will protect water resources, reduce the consumption of water, reduce the loss or waste of water, improve the efficiency in the use of water, and increase the recycling and reuse of ...
Texas Water Development Board
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Monitoring Seasonal Hydrological Dynamics of Minerotrophic Peatlands Using Multi-Date GeoEye-1 Very High Resolution Imagery and Object-Based Classification

Remote Sensing, 2012
The La Grande River watershed, located in the James Bay region (54°N, Quebec, Canada), is a major contributor to the production of hydroelectricity in the province. Peatlands cover up to 20% of the terrestrial environment in this region.
Monique Bernier, Karem Chokmani, Yann Dribault   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Arizona department of water resources: Securing Arizona\u27s water future

, 1998
The Arizona Department of Water Resources works to secure long-term dependable water supplies for Arizona\u27s communities. The Department: administers and enforces Arizona\u27s groundwater code, and surface water rights laws (except those related to ...
Arizona Department of Water Resources
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Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Other title: Kansas Municipal Water Conservation Plan Guidelines; Other title: Municipal Water Conservation Plan Guidelines

, 2007
application/pdf; "August 2007.", "Prepared cooperatively by: Kansas Water Office, Kansas Department of Agriculture, Division of Water Resources, Kansas Department of Health & Environment, Division Of Environment, Bureau of Water, [and] Kansas Rural ...
Kansas Water Office.
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Study on the Impact of Groundwater and Soil Parameters on Tunnel Deformation and Sensitivity Analysis

Applied Sciences
Based on the Xiaolangdi North Bank Irrigation Area Project, this study combines numerical simulation and BP neural network methods to investigate the sensitivity of tunnel soil and its parameter inversion under continuous heavy rainfall.
Yongxin Li, Zhimin Zhang, Jinyu Dong, Bobo Wang, Chuang Wang   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source