Results 71 to 80 of about 2,393,042 (266)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Floods types in a mountain catchment: The Ochotnica River, Poland

Acta Geographica Slovenica, 2019
This paper presents the results of a study on floods in the Ochotnica River catchment during forty years of hydrological observations (1972–2011). The Ochotnica River is located in the Gorce Mountains, in the Polish Western Carpathians.
Małgorzata Kijowska-Strugała, Anna Bucała-Hrabia   +1 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Impact of Three Gorges Reservoir Operation on Water Level at Jiujiang Station and Poyang Lake in the Yangtze River

Hydrology
The variation in water level at Jiujiang Station (JJS) directly affects flow exchange between the Yangtze River and the Poyang Lake. Quantitative research on the influencing factors of water level changes at JJS is of great importance for water supply ...
Yun Wang, Shenglian Guo, Xin Xiang, Chenglong Li, Na Li   +4 more
doaj   +1 more source

Sea level variability in South African estuaries

South African Journal of Science, 2013
Sea level variability in the coastal ocean affects water levels in adjacent estuaries over a wide range of periods and to varying distances landward. An assessment is given here of the responses of a number of South African estuaries, focusing on tidal ...
Eckart H. Schumann
doaj   +1 more source

An improved water-level [PDF]

Journal of the Franklin Institute
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openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Monitoring Seasonal Hydrological Dynamics of Minerotrophic Peatlands Using Multi-Date GeoEye-1 Very High Resolution Imagery and Object-Based Classification

Remote Sensing, 2012
The La Grande River watershed, located in the James Bay region (54°N, Quebec, Canada), is a major contributor to the production of hydroelectricity in the province. Peatlands cover up to 20% of the terrestrial environment in this region.
Monique Bernier, Karem Chokmani, Yann Dribault   +2 more
doaj   +1 more source