Results 61 to 70 of about 2,393,042 (266)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Трансформация экосистем, 2019 In the channel areas of the large Tayshir Reservoir valley, zooplankton is unevenly distributed along the longitudinal profile. The number and biomass of communities increases from the upper to lower rea ches. In the Durgun Reservoir, which has features
Аlexander V. Krylov +3 more
doaj +1 more source
Water Levelling - A Suggestion [PDF]
Australian Archaeology, 1978 Water levelling is a simple, rapid and reliable way of levelling on archaeological sites, yet it seems to be somewhat under-used in favour of other methods such as dumpy or line levels. This is probably because water levels tend to be do-it-yourself contraptions, requiring some experimentation.
openaire +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Spaceborne GNSS-R Observation of Global Lake Level: First Results from the TechDemoSat-1 Mission
Remote Sensing, 2019 Spaceborne global navigation satellite system reflectometry (GNSS-R) data collected by the UK TechDemoSat-1 (TDS-1) satellite is applied to retrieve global lake levels for the first time.
Liwen Xu +5 more
doaj +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Applied SciencesRecently, heavy rains caused by climate change have resulted in dam failures due to overtopping. This study presents a design method aiming to prevent overtopping failures by applying gabion retaining walls at the dam crest. Simulations, experiments, and
Dal-Won Lee +5 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The Wave Amplification Mechanism of Resonant Caisson
Journal of Marine Science and EngineeringPrevious studies have introduced a resonant caisson designed to enhance wave energy extraction in regions with low wave energy density; however, its operational mechanism remains poorly understood.
Jiawei Hao +3 more
doaj +1 more source