Results 41 to 50 of about 3,719,932 (269)

Water marketing effects on crop-water management

open access: yesCalifornia Agriculture, 1989
This study considers a water marketing system in which farmers can buy a given amount of water, at a fixed price, and sell the amount not used. The system could induce farmers to upgrade their irrigation systems and reduce water application and drainage ...
J Letey, A Dinar
doaj  

Income growth, population and savings in the Southern Africa Development Community region

open access: yesSouth African Journal of Economic and Management Sciences, 2018
Background: The Southern Africa Development Community (SADC) faces pervasive income stagnation, high inequality, increasing population growth rates and poverty.
Greenwell Matchaya   +2 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Ground-water management

open access: yesCalifornia Agriculture, 1977
If adequate water supplies are to be continually available, and if Periods Of drought are to be dealt with effectively, management of ground water is essential on every farm and in every city county, water district, and region using ground-water ...
V Scott, J Scalmanini
doaj  

Sample size requirements for riverbank macrolitter characterization

open access: yesFrontiers in Water, 2023
Anthropogenic litter is omnipresent in terrestrial and freshwater systems, and can have major economic and ecological impacts. Monitoring and modeling of anthropogenic litter comes with large uncertainties due to the wide variety of litter ...
Sjoukje I. de Lange   +14 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Evaluation of groundwater quality for irrigation and drinking purposes in Barishal district of Bangladesh

open access: yesFundamental and Applied Agriculture, 2019
A study was conducted to evaluate the quality of groundwater in Barishal district of Bangladesh for both irrigation and drinking purposes. Sixty water samples were collected and analyzed in the Biochemistry laboratory of Bangladesh Agricultural ...
Gulshan Yasmin   +4 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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