Results 51 to 60 of about 685,876 (281)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Observed water-mass characteristics and circulation off Prydz Bay, East Antarctica

Frontiers in Marine Science
Circulation and water masses in the greater Prydz Bay region were surveyed in the austral summer 2021 (January-March) during the ‘Trends in Euphausiids off Mawson, Predators and Oceanography’ (TEMPO) experiment, and are described in this paper.
Annie Foppert, Annie Foppert, Sophie Bestley, Sophie Bestley, Elizabeth H. Shadwick, Elizabeth H. Shadwick, Andreas Klocker, Andreas Klocker, Clara R. Vives, Clara R. Vives, Clara R. Vives, Clara R. Vives, Guillaume Liniger, Guillaume Liniger, Guillaume Liniger, Karen J. Westwood, Karen J. Westwood   +16 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Первое наблюдение холодного промежуточного слоя на шельфе Антарктического полуострова

Український антарктичний журнал, 2016
Впервые по данным подробной океанографической съемки, проведенной в период 17-й Украинской антарктической экспедиции (2012-2013), исследована структура водных масс региона архипелага Аргентинские острова.
I.P. Neverovsky, Y. I. Popov, V.N. Sytov, A. S. Matygin   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Passive tracers in a general circulation model of the Southern Ocean [PDF]

, 1999
Passive tracers are used in an o?-line version of the United Kingdom Fine Resolution Antarctic Model (FRAM) to highlight features of the circulation and provide information on the inter-ocean exchange of water masses.
Stevens, DP, Stevens, IG
core   +3 more sources

Water Mass Formation from Revised COADS Data [PDF]

Journal of Physical Oceanography, 1995
Surface heat and freshwater fluxes from the Comprehensive 0cean-Atmosphere Data Set are revised and used diagnostically to compute air-sea transformation rates on density, temperature, and salinity classes over the domain of the data. Maximum rates occur over the warmest water and over mode waters, which are the dominant result of air-sea interaction ...
Speer, K. G., Isemer, H.-J., Biastoch, Arne   +2 more
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Sensitivity of fish diel vertical migration depths to future changes in the Pacific Ocean oxygen minimum zone

Frontiers in Marine Science
Diel vertical migrations in the ocean play a key role in predator-prey dynamics and the functioning of the biological carbon pump. However, changes in ocean conditions including warming and deoxygenation threaten to significantly perturb vertical ...
Sam Ditkovsky, Laure Resplandy, Laure Resplandy, Laureline Dalaut, Nicolas Barrier, Matthieu Lengaigne, Olivier Maury   +6 more
doaj   +1 more source

Height-resolved Scaling Properties of Tropospheric Water Vapour based on Airborne Lidar Observations [PDF]

, 2013
Two-dimensional vertical water vapour cross sections of the free troposphere between altitudes of 2 and 10 km, measured by nadir-viewing airborne differential-absorption lidar with high spatial resolution, were analyzed using structure functions up to ...
Craig, George C., Fischer, Lucas, Kiemle, Christoph   +2 more
core