Results 61 to 70 of about 685,876 (281)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Observed features of the water masses in the Halmahera Sea in November 2016
Ilmu Kelautan, 2021 Halmahera Sea is one of the locations in the eastern route of Indonesian Throughflow (ITF), where high salinity water is mainly transported by the ITF.
Mochamad Riza Iskandar +3 more
doaj +1 more source
Mass imbalances in EPANET water-quality simulations [PDF]
Drinking Water Engineering and Science, 2017 Abstract. EPANET is widely employed to simulate water quality in water distribution systems. However, in general, the time-driven simulation approach used to determine concentrations of water-quality constituents provides accurate results only for short water-quality time steps. Overly long time steps can yield errors in concentration estimates and can
M. J. Davis, R. Janke, T. N. Taxon
openaire +4 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Impact of Freshwater Inflow From the Volturno River on Coastal Circulation
Frontiers in Marine Science, 2020 The coastal area located in front of the Volturno river estuary (the Gulf of Gaeta, central-eastern Tyrrhenian Sea) was synoptically sampled in seven surveys between June 2012 and October 2014.
Roberto Sorgente +9 more
doaj +1 more source
Stable and habitable systems with two giant planets
, 2010 We have studied planetary systems which are similar to the Solar System and built up from three inner rocky planets (Venus, Earth, Mars) and two outer gas giants.
Batygin K +5 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Anthropogenic CO2 in the Azores region
Scientia Marina, 2010 The AZORES-I cruise was conducted in August 1998, spanning the length of three latitudinal large-scale sections at 22, 28 and 32ºW. The oceanic carbon system was oversampled by measuring total alkalinity, total inorganic carbon and pH.
Fiz F. Pérez +3 more
doaj +1 more source
Neodymium isotopic composition and concentration in the western North Atlantic Ocean: results from the GEOTRACES GA02 section [PDF]
, 2015 The neodymium (Nd) isotopic composition of seawater is commonly used as a proxy to study past changes in the thermohaline circulation. The modern database for such reconstructions is however poor and the understanding of the underlying processes is ...
Coles, B +9 more
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source