Results 81 to 90 of about 687,649 (293)

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Changes in hydrodynamics and nutrient load of the coastal bay induced by Typhoon Talim (2023)

Frontiers in Marine Science
Typhoons can greatly alter the hydrodynamic and nutrient supply in coastal oceans. However, due to the complex conditions of typhoons, such as their intensity, even slight changes may cause substantial changes in hydrodynamics and nutrient supply, which ...
Chunqing Chen, Chunqing Chen, Qibin Lao, Qibin Lao, Xin Zhou, Qingmei Zhu, Qingmei Zhu, Fajin Chen, Fajin Chen, Fajin Chen   +9 more
doaj   +1 more source

Abyssal Atlantic circulation during the Last Glacial Maximum: Constraining the ratio between transport and vertical mixing [PDF]

, 2010
The ocean’s role in regulating atmospheric carbon dioxide on glacial‐interglacial timescales remains an unresolved issue in paleoclimatology. Reduced mixing between deep water masses may have aided oceanic storage of atmospheric CO_2 during the Last ...
Andrews, Boyle, Broecker, Curry, Curry, D. C. Lund, Duplessy, Duplessy, Ganachaud, Gebbie, Gherardi, Gouretski, Herguera, Hodell, J. F. Adkins, Kallel, Keeling, Keigwin, Kim, Knox, Kunze, Large, Ledwell, LeGrand, LeGrande, Lumpkin, Lynch-Stieglitz, Marchal, Monnin, Morris, Munk, Neftel, Ninnemann, Nurser, Oppo, Ostermann, Plumb, Polzin, R. Ferrari, Robinson, Sarmiento, Schlosser, Siegenthaler, Sigman, Speer, Speer, Stammer, Toggweiler, Wunsch, Wunsch, Zahn   +50 more
core   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Структура водных масс в регионе архипелага Аргентинские острова

Український антарктичний журнал, 2016
Структура водных масс региона архипелага Аргентинские острова была исследована по данным мас­штабной океанографической съемки, выполненной специалистами 17 Украинской антарктической экспедиции.
I. P. Neverovsky, Y. I. Popov, V. N Sytov, A. S. Matygin   +3 more
doaj   +1 more source

Extremely Luminous Water Vapor Emission from a Type 2 Quasar at Redshift z = 0.66

, 2005
A search for water masers in 47 Sloan Digital Sky Survey Type 2 quasars using the Green Bank Telescope has yielded a detection at a redshift of z = 0.660.
Baudry A., Haas M., Richard Barvainis, Robert Antonucci   +3 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

The characteristics of nutrient distribution and influencing factors in the Chukchi Plateau and adjacent waters

Frontiers in Marine Science
The Arctic is one of the regions under the most dramatic climate change. Global warming has led to elevated freshwater inflow into the western Arctic Ocean and significantly altered nutrient structure and biogeochemical cycling.
Zhixin Ni, Zhixin Ni, Han Zhang, Minxia Zhang, Tuanjie Li, Shengyong Li, Xin Chen, Ling Zhang, Yuan Gao, Changshu Chen, Zhongyuan Wang, Wei Deng, Hai zhou Zhang   +12 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source