Results 51 to 60 of about 201,786 (264)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Water striders adjust leg movement speed to optimize takeoff velocity for their morphology
Nature Communications, 2016 How water striders escape from danger by jumping vertically from the water surface without sinking is an open question in biomechanics. Yanget al. show that water strider species with varying leg lengths and body masses tune their leg movements to ...
Eunjin Yang +4 more
doaj +1 more source
Frontiers in Earth Science, 2018 The Quillcay catchment in the Cordillera Blanca, Peru, contains several glacial lakes, including Lakes Palcacocha (with a volume of 17 × 106 m3), Tullparaju (12 × 106 m3), and Cuchillacocha (2 × 106 m3).
Holger Frey +6 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The Italian water movement and the politics of the commons
Water Alternatives, 2016 The article contributes to the debate on the commons as a political strategy to counter the privatisation of water services by focusing on the experience of the Italian water movement.
Chiara Carrozza , Emanuele Fantini
doaj
Ciencias Marinas, 2015 The common dolphinfish (Coryphaena hippurus) is an important resource for the sport-fishing industry in Mexico. It is captured incidentally by the eastern Pacific purse-seine tuna fishery and in coastal areas by artisanal fisheries.
Cristina Hernández-Tlapale +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Movement of Water in Glaciers [PDF]
Journal of Glaciology, 1972 AbstractA network of passages situated along three-grain intersections enables water to percolate through temperate glacier ice. The deformability of the ice allows the passages to expand and contract in response to changes in pressure, and melting of the passage walls by heat generated by viscous dissipation and carried by above-freezing water causes ...
openaire +1 more source