Results 71 to 80 of about 220,405 (309)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Movement of Water in Glaciers [PDF]
Journal of Glaciology, 1972 AbstractA network of passages situated along three-grain intersections enables water to percolate through temperate glacier ice. The deformability of the ice allows the passages to expand and contract in response to changes in pressure, and melting of the passage walls by heat generated by viscous dissipation and carried by above-freezing water causes ...
openaire +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
, 2010 Descripció del recurs: el 02 de novembre de 2010Dominant economic growth and nation-state building practices are often based on detaching individuals from other individuals and communities from their natural environment in which their livelihoods used to
Ilhan, Akgün +1 more
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Moved to act: communication supporting HIV social movements to achieve inclusive social change
, 2009 Social movements have generated interest in development circles since the mid-1990s as relatively independent expressions of civil society, mobilising people to set their own development priorities and agendas for issues as diverse as water privatisation,
Vincent, Robin, Stackpool-Moore, Lucy
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Discourses and Conditions of Possibility in Latin American Social Movements: The Cases of the Bolivian 'Water War' and the Movement of Opposition against the New Airport in Mexico City [PDF]
This work presents a comparative analysis of two Latin American social movements. The first case is the movement of opposition against the privatisation of water and sanitation services (WSS) in Cochabamba, Bolivia and the second case is the movement of ...
J Carlos Dominguez (QEH)
core
Ciencias Marinas, 1993 Horizontal and vertical movements are described for four scalloped hammerhead sharks (Sphyrna lewini) tagged with ultrasonic transmitters. The trackings were carried out during August 1986, 1988-1989, and July 1989 in the pelagic environment surrounding
AP Klimley +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source