Results 91 to 100 of about 18,853,489 (341)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Influence of Returned Water from Sludge Treatment and Return Activated Sludge on 2-Methylisoborneol and Geosmin Behaviors and Concentrations during Wastewater Treatment

Journal of Water and Environment Technology
Compounds such as 2-methylisoborneol (2-MIB) and geosmin present in the final effluents of wastewater treatment plants may affect water treatment in downstream areas. To reduce the concentrations of 2-MIB and geosmin, we investigated the influence of the
Ko Hosoda, Mitsuharu Nishikawa, Yasutaka Yasui, Kento Iwatani, Tomoyuki Ohara, Syunichiro Fujiwara, Toshiharu Segawa   +6 more
doaj   +1 more source

Evaluation of nutrient stoichiometric relationships among ecosystem compartments of a subtropical treatment wetland. Do we have “Redfield wetlands”?

Ecological Processes, 2019
Background Evaluation of carbon (C), nitrogen (N), and phosphorus (P) ratios in aquatic and terrestrial ecosystems can advance our understanding of biological processes, nutrient cycling, and the fate of organic matter (OM) in these ecosystems ...
Paul Julian, Stefan Gerber, Rupesh K. Bhomia, Jill King, Todd Z. Osborne, Alan L. Wright, Matthew Powers, Jacob Dombrowski   +7 more
doaj   +1 more source

Water Quality Characteristic of Ciliwung River at Bogor Botanical Garden Segmen, Bogor [PDF]

, 2017
Ciliwung river is a river with water quality classified in moderate poluted until heavy polluted due to the high pollution load and lack of open green space in river banks, except in some area including Bogor Botanical Garden (KRB).
Priyono, A. (Agus), Rushayati, S. B. (Siti), Sujati, A. B. (Aditya)   +2 more
core  

The status of river water quality in some rural areas, in state of Johor and its effects to life [PDF]

, 2018
Water is a basic requirement of human and other life. Water resources stems from rivers, streams, drains, ponds and so forth. The river is the natural water resources are very important for a human habitat.
Md. Yassin, Azlina, Miskam, Nurasyikin, Shafii, Haryati, Shareh Musa, Sharifah Meryam   +3 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Building schematic of Vienna in the late 1920s

Scientific Data, 2021
Measurement(s) building • Historical Data Type Technology Type(s) digital curation • optical character recognition • regular expression Factor Type(s) district Sample Characteristic - Environment city Sample Characteristic - Location Vienna Machine ...
Ulrich Kral, Ferdinand Reimer, Havvanur Tuz, Ingeborg Hengl   +3 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

National Ambient Water Quality Criteria.................................................................... 7-9 Agricultural Water Quality Limits................................................................................. 7-9 [PDF]

US Geological Survey (USGS)........................................................................................
Surface Water Quality
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