Results 151 to 160 of about 17,487,572 (398)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Evaluating the Combined Effects of Water and Fertilizer Coupling Schemes on Pear Vegetative Growth and Quality in North China [PDF]

, 2023
Yanan Liu, Meijian Bai, Yinong Li, Baozhong Zhang, Xianbing Wu, Yuan Shi, Hairuo Liu   +6 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A novel fabrication method of vertically aligned carbon nanotubes by single-stage floating catalyst CVD

BMC Chemistry
The single-stage floating catalyst chemical vapor deposition (SS-FCCVD) method using the ferrocene route (e.g., ferrocene: catalyst and camphor: carbon source) offers significant but largely unexplored versatility for the production of carbon nanotubes ...
B. V.N. Sewwandi, A. R. Kumarasinghe, Xing CHEN, P. M.C.J. Bandara, L. Jayarathna, Rohan Weerasooriya   +5 more
doaj   +1 more source

The potential role of socio-hydrological models for participatory water governance in Burkina Faso [PDF]

, 2020
Halting and reversing water quality degradation is a major global concern. The variety of needs and priorities placed on water resources make the issue of water pollution multifaceted and complex.
Barendrecht, Marlies, Carr, Gemma, Debevec, Liza   +2 more
core  

Interaction Effects of Nitrogen Source and Irrigation Regime on Tuber Quality, Yield, and Water Use Efficiency of Solanum tuberosum L. [PDF]

, 2020
Mohamed A. M. Eid, A. A. Abdel-Salam, Haythum M.S. Salem, Samira Mahrous, Mahmoud F. Seleiman, Abdullah A. Alsadon, T.H.I. Solieman, Abdullah Ibrahim   +7 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Unveiling the potential: Recent developments in carbon nanomaterial synthesis from soot and its application for desalination

Next Nanotechnology
In the realm of nanotechnology, carbon-based materials stand as a testament to how nature's simplest element can inspire boundless innovation. However, challenges including defect-free synthesis, high production costs, purification or separation ...
Aruna Yadav, Vikash Chandra Janu, Deepesh Patidar, Pooja Sharma, Prashant Vasistha, Surender Kumar   +5 more
doaj   +1 more source

Water quality issues in the Illinois River watershed: A proposal for new voluntary incentives [PDF]

, 2006
Concerns about water quality degradation exist in Northwest Arkansas. The purpose of this study was to analyze the potential usefulness of U.S. conservation programs in addressing water quality concerns on farms in the Illinois River watershed as well as
Hodges, Tory B., Popp, Jennie S.
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source