Results 151 to 160 of about 18,853,489 (341)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Managing nitrogen legacies to accelerate water quality improvement
Nature Geoscience, 2022 N. Basu +12 more
semanticscholar +1 more source
An Analysis of Water Related Infrastructure Spending in Georgia [PDF]
, 2010 This report examines the effects of past Georgia state and local government infrastructure investments and conservation policies on water quality and quantity and explores the necessary infrastructure investment to maintain future water quality and ...
Peter Bluestone
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Inspection of Drinking Water Quality on the Regional Preparation of Zona Air Minum Prima (Zamp) Pdam Tirta Musi Palembang [PDF]
, 2010 Background : Public access to water with quality ready to drink increased. This is important because the water borne disease can arise due to the water quality does not meet health requirements.
Desiandi, M. (Muhammad) +2 more
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Fuzzy Logic Water Quality Index and Importance of Water Quality Parameters
Air, Soil and Water Research, 2009 Determination of status of water quality of a river or any other water sources is highly indeterminate. It is necessary to have a competent model to predict the status of water quality and to advice for type of water treatment for meeting different ...
Raman Bai. V +2 more
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Recent biotechnological applications of value-added bioactive compounds from microalgae and seaweeds
Botanical StudiesMicroalgae and seaweed have been consumed as food for several decades to combat starvation and food shortages worldwide. The most famous edible microalgae species are Nostoc, Spirulina, and Aphanizomenon, in addition to seaweeds, which are used in ...
Salma N. Eladl +2 more
doaj +1 more source