Results 141 to 150 of about 486,083 (311)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Class frequency distribution for a surface raw water quality index in the Vaal Basin [PDF]

, 2014
A harmonised in-stream water quality guideline was constructed to develop a water quality index for the Upper and Middle Vaal Water Management Areas, in the Vaal basin of South Africa.
Dzwairo, Bloodless, Otieno, Fredrick Alfred O.   +1 more
core   +1 more source

Assessment of Water Quality of El Oulfa Wetland (Morocco) Using the Water Quality Index and the Trophic State IndeX

Journal of Sustainable Development of Energy, Water and Environment Systems
Water quality degradation is one of the most pressing environmental challenges in reservoirs around the world, making the trophic status assessment essential for restoration and sustainable use.
Badr Nachchach, Halima Jounaid, Mohamed Taoufik, Nihad Chakri, Fouad Amraoui, Touria Ould Bellahcen   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Groundwater Quality Assessment at East El Minia Middle Eocene Carbonate Aquifer: Water Quality Index (WQI) and Health Risk Assessment (HRA) [PDF]

Around the world, groundwater supply is critical for vital needs such as drinking and irrigation. This work investigates groundwater in the carbonate aquifer of the Middle Miocene in the east El Minia area, Egypt.
Mariacrocetta Sambito, Abdel-Aziz A. Abdel-Aziz, Mohamed S. Ahmed, Moustafa Gamal Snousy, Alaa Mostafa, Esam Ismail, Ramadan S. A. Mohamed, Salman A. Salman   +7 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Assessment of hydrogeochemistry in groundwater using water quality index model and indices approaches. [PDF]

Heliyon, 2023
Uddin MG, Diganta MTM, Sajib AM, Hasan MA, Moniruzzaman M, Rahman A, Olbert AI, Moniruzzaman M.   +7 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Monitoring water quality and eutrophication phenomenon of Azad Dam using Iranian Water Quality Index and Carlson's Trophic State Index

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2017
Water reservoirs have an important role in providing water for drinking and agriculture. It is necessary to protect these resources. This study was conducted to determine water quality of Azad Reservoir (Kordestan-Sanandaj) based on Iranian Water Quality
A. Makhloogh; H. Nasrollahzadeh saravi; F. Parafkandeh; H. Fazli; R. Mirzaei; H. Hosseinpor; A. Keyhansani; M. Dostdar
doaj