Results 141 to 150 of about 489,039 (311)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Class frequency distribution for a surface raw water quality index in the Vaal Basin [PDF]

, 2014
A harmonised in-stream water quality guideline was constructed to develop a water quality index for the Upper and Middle Vaal Water Management Areas, in the Vaal basin of South Africa.
Dzwairo, Bloodless, Otieno, Fredrick Alfred O.   +1 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Groundwater Quality Assessment at East El Minia Middle Eocene Carbonate Aquifer: Water Quality Index (WQI) and Health Risk Assessment (HRA) [PDF]

Around the world, groundwater supply is critical for vital needs such as drinking and irrigation. This work investigates groundwater in the carbonate aquifer of the Middle Miocene in the east El Minia area, Egypt.
Mariacrocetta Sambito, Abdel-Aziz A. Abdel-Aziz, Mohamed S. Ahmed, Moustafa Gamal Snousy, Alaa Mostafa, Esam Ismail, Ramadan S. A. Mohamed, Salman A. Salman   +7 more
core   +1 more source

Assessment of Water Quality of El Oulfa Wetland (Morocco) Using the Water Quality Index and the Trophic State IndeX

Journal of Sustainable Development of Energy, Water and Environment Systems
Water quality degradation is one of the most pressing environmental challenges in reservoirs around the world, making the trophic status assessment essential for restoration and sustainable use.
Badr Nachchach, Halima Jounaid, Mohamed Taoufik, Nihad Chakri, Fouad Amraoui, Touria Ould Bellahcen   +5 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

The Role of Water Quality Perceptions in Modeling Lake Recreation Demand [PDF]

Recreation demand models typically incorporate measures of the physical attributes of recreational sites; e.g., Secchi depth or phosphorous levels in case of water quality.
Kling, Catherine L., Jeon, Yongsik, Herriges, Joseph A., Downing, John A.   +3 more
core