Results 121 to 130 of about 489,039 (311)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Water Quality Index of Arkavathi River and Surrounding Groundwater

International Journal of Environmental Health Engineering
Aim: Finding out the water quality of Arkavathi river, a tributary of the Kaveri system and surrounding groundwater is the aim of the present work using the water quality index (WQI) method.
M Bharath, K Arun Kumar, Syed Ariff
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Characterization of Water Quality in Torehalla Watershed, Karnataka, India-Based on Water Quality Index [PDF]

, 2014
The quality of drinking water is a powerfulenvironmental determinant for human health. Assured drinking water is afoundation for the prevention and control of waterborne diseases. All over theworld, human population has inadequate access to potable water
Suresh, T.S., Manjunath, H.N.
core  

Effect of Water Management Technology Used in Trout Culture on Water Quality in Fish Ponds [PDF]

, 2018
Pond management requires that a specific fish culture is conducted while taking into account both production possibilities and profitability, as well as the impact it may have on the natural environment.
Ireneusz Cymes, Marcin Sidoruk
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Integrating Water Quality Index (WQI) and Multivariate Statistics for Regional Surface Water Quality Evaluation: Key Parameter Identification and Human Health Risk Assessment [PDF]

Assessing regional water quality and evaluating the associated risks to human health posed by aquatic contaminants are paramount for conserving and managing surface water resources and formulating effective local policy decisions.
Lingshuang Zhong, Yao Feng, Huajie Xia, Huabin Liu, Yu Lu, Wenjuan Zhou, Huoqian Luo, Xizhi Nong   +7 more
core   +1 more source

Land use from water quality: development of a water quality index across Pennsylvania streams

Ecosphere, 2019
Anthropogenic stressors to lotic environments are diverse and often act in complex and synergistic ways through space and time. The need to adequately quantify and communicate these stressors in lotic environments is important for assessing stream health
Timothy A. Wertz, Matthew K. Shank
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source