Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Correlation of various water quality parameters and water quality index of districts of Uttarakhand
Environmental and Sustainability Indicators, 2021 This study is based on hydrogeochemical and biological parameters and calculation of Water Quality Index (WQI) to assess water quality of a rural tract in five districts of Garhwal and Kumaon district of Uttarakhand, India.
Vinod Kothari +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Modification of the Water Quality Index (WQI) Process for Simple Calculation Using the Multi-Criteria Decision-Making (MCDM) Method: A Review [PDF]
, 2021 Human activities continue to affect our water quality; it remains a major problem worldwide (particularly concerning freshwater and human consumption).
Naseem Akhtar +7 more
core +1 more source
Water quality assessment of rivers in Lake Chaohu Basin (China) using water quality index
Ecological Indicators, 2021 This study aims at assessment the water quality condition in the rivers of Lake Chaohu Basin (LCB), and exploring the crucial parameters affecting its water quality.
Zhaoshi Wu, Xijun Lai, Kuanyi Li
doaj +1 more source
A water quality index for recreation in Brazilian freshwaters [PDF]
Journal of Water and Health, 2015 Use of water for leisure activities has long been prevalent in human societies, especially where the climate is favorable. Water resources with appealing conditions for primary contact recreational activities include rivers, waterfall plunge pools, dams and lakes, as well as sea coasts.
F W, Azevedo Lopes +3 more
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Evaluation of the Water Quality of River Kaduna, Nigeria Using Water Quality Index
Journal of Applied Sciences and Environmental Management, 2017 Twelve (12) water quality parameters (turbidity, TDS, pH, Cl- , EC, DO, BOD5, COD, total nitrogen, total phosphorus, Fe and Mn) were analyzed in River Kaduna, Nigeria on a monthly basis for a period of one year in 15 sampling locations using standard ...
FJ Ogbozige, DB Adie, SB Igboro, A Giwa
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source