Results 81 to 90 of about 834,737 (262)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

A Conflict Resolution Model for Water Allocation and River Water Quality Management [PDF]

آب و فاضلاب, 2007
In this study, a conflict resolution methodology for water quality management in a river system is presented. The proposed model maximizes an objective function based on the Nash product which includes different utility functions related to the water ...
Ali Moridi, Mohammad Karamouz
doaj  

Numerical Simulations of Water Quality Measurement Model in an Opened-Closed Reservoir with Contaminant Removal Mechanism

International Journal of Differential Equations, 2018
The mathematical simulation of water contaminant measurement is often used to assess the water quality. The monitoring point placement for water quality measurement in an opened-closed reservoir can give accurate or inaccurate assessment.
Kaboon Thongtha, Jaipong Kasemsuwan
doaj   +1 more source

WASP 8: The Next Generation in the 50-year Evolution of USEPA's Water Quality Model. [PDF]

Water (Basel), 2020
Wool T, Ambrose RB, Martin JL, Comer A.
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

An optimized ensemble ML-WQI model for reliable water quality prediction by minimizing the eclipsing and ambiguity issues

Applied Water Science
Monitoring water quality is essential for the sustenance of the ecosystem and various forms of life on Earth. The water quality index (WQI) models are the widely adopted approach to water quality monitoring.
Ashifur Rahman, M. M. Mahbubul Syeed, Md. Rajaul Karim, Kaniz Fatema, Razib Hayat Khan, Mohammad Faisal Uddin   +5 more
doaj   +1 more source

Deep Learning for Water Quality Prediction—A Case Study of the Huangyang Reservoir

Applied Sciences
Water quality prediction is a fundamental prerequisite for effective water resource management and pollution prevention. Accurate predictions of water quality information can provide essential technical support and strategic planning for the protection ...
Jixuan Chen, Xiaojuan Wei, Yinxiao Liu, Chunxia Zhao, Zhenan Liu, Zhikang Bao   +5 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Towards benchmarking an in-stream water quality model [PDF]

Hydrology and Earth System Sciences, 2007
A method of model evaluation is presented which utilises a comparison with a benchmark model. The proposed benchmarking concept is one that can be applied to many hydrological models but, in this instance, is implemented in the context of an in-stream ...
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source